St. Louis Blues vs New York Islanders Prediction, Odds and Picks for Today, 11/22/25

The New York Islanders host the St. Louis Blues on Saturday at UBS Arena. The Islanders are coming off a 5-0 win over the Red Wings in a game where Ilya Sorokin picked up his 2nd shutout of the season. Sorokin has dominated since the calendar flipped to November, sporting a strong .939 save percentage and 1.80 goals-against average over 6 starts. He’s projected to get the starting nod again in this one, which will be his first home start since November 4. His recent hot streak has mostly come on the road, and his numbers on the season are far better away from UBS Arena. More specifically, Sorokin’s save percentage on the season drops from .915 on the road to .880 at home and his goals-against average dips from 2.39 to 3.51.

This will be New York’s first game at home since November 7, as they are coming off an 8-game road trip. After such a dominant performance to close out the trip, New York may be getting too comfortable ahead of this matchup. The first home game after an extended road trip can be sneakily dangerous, and while the Blues haven’t been off to a strong start this season, they are playing better recently. St. Louis is riding a 3-game losing streak, but 3 of those losses came in overtime or a shootout. Don’t be surprised if the Blues pull off the mild upset here.

Blues vs Islanders prediction: St. Louis ML (+100) available at time of publishing. Playable at that number.

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