Vegas Golden Knights vs St. Louis Blues Prediction, Odds and Picks for Today, 11/15/25

The Vegas Golden Knights have gone cold, as they enter this matchup against the St. Louis Blues riding a 4-game losing streak. However, going up against a St. Louis team that has been among the most disappointing teams in the NHL so far this season gives the Golden Knights a great chance to get back into the win column. It’s not like the VGK have spiraled, as 3 of their 4 losses on their current losing streak have come by a single goal, with 2 coming in overtime. Vegas also has the rest advantage in this one, as the Blues lost a heartbreaker to the Flyers by a score of 6-5 in a shootout on Friday night.

Jordan Binnington got the start for the Blues on Friday, which means we will most likely see Joel Hofer between the pipes in this one. Hofer has struggled in 2025, owning a less-than-ideal .865 save percentage to go along with a 4.05 goals-against average. The Blues as a team are allowing a 3.76 goals per game, which is the 2nd-most in the NHL. Thus, this matchup creates a great opportunity for a well-rounded forward group for Vegas to get rolling. Take confidence fading the Blues and back the Golden Knights on the moneyline.

Golden Knights vs Blues prediction: Golden Knights ML (-150) available at time of publishing. Playable to -165.