Vegas Golden Knights vs St. Louis Blues Prediction, Odds and Picks for Today, 11/15/25

The Vegas Golden Knights have gone cold, as they enter this matchup against the St. Louis Blues riding a 4-game losing streak. However, going up against a St. Louis club that has been among the most disappointing teams in the NHL so far this season gives the Golden Knights a great chance to get back into the win column. It’s not like the Vegas have spiraled, as 3 of its 4 losses on the current skid have come by a single goal — including 2 in overtime. Vegas also has the rest advantage in this one, as the Blues lost a heartbreaker to the Flyers 6-5 in a shootout on Friday night.

Jordan Binnington got the start for the Blues on Friday, which means we will most likely see Joel Hofer between the pipes in this one. Hofer has struggled in 2025, owning a less-than-ideal .865 save percentage to go along with a 4.05 goals-against average. The Blues as a team are allowing a 3.76 goals per game, which is the second most in the NHL. Thus this matchup creates a great opportunity for a well-rounded forward group for Vegas to get rolling. Take confidence fading the Blues, so let’s back the Golden Knights on the money line.

Golden Knights vs Blues prediction: Vegas ML (-150) available at time of publishing. Playable to -165.

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