Pickswise
Colorado
Sep 2612:00 PM
Baylor
DetailsPicks1AnalysisBest BetsParlays

Colorado vs Baylor Prediction, Odds and NCAAF Picks for Saturday, 09/26/26

Colorado
Baylor
ColoradoBaylor
College FootballSat, Sep 2612:00 PM
Point Spread PickCFB

The Baylor Bears host the Colorado Buffaloes on Saturday as Big 12 conference play gets started for both teams. Colorado had a sneaky win over Georgia Tech in their season opener, but they were blasted by Northwestern last weekend in a game where they turned the ball over 4 times and couldn’t generate much offense. Baylor lost the opener to Auburn, where they piled up tons of offense but only 16 points. They have won their two lower-level matchups since then, but there are still lots of questions here. I don’t ever love laying a lot of points with Baylor because their games have so much volatility baked in, but I think they are quite a bit better than Colorado. I’ll take Baylor -10, and I expect this line to expand a bit as the week goes on.

Baylor QB DJ Lagway suffered an ankle injury against Florida that caused him to sit the next two games. Baylor could get by without him, so they opted for caution and let him rest. Lagway can be turnover-prone, but the upside is definitely there, and he throws one of the prettier balls in the game (when it is on target). Baylor’s defense is better than we expected too, and I think this team has a chance to compete in the second tier of the Big 12. Colorado should be at the bottom of this conference. They have very little depth, and they aren’t great in the trenches on either side. They need things to bounce their way, and they try to survive on some creative playcalling and taking chances down the field. It is a boom-or-bust world for the Buffs. I just don’t think it will work out for them most weeks. Give me the Bears.

Colorado vs Baylor prediction: Baylor -10 (-120) available at time of publishing. Playable to -12.5.

Exclusive Offers
See all
Polymarket — Deposit $10, Get a $50 Trading Bonus
Polymarket
PolymarketDeposit $10, Get a $50 Trading Bonus
$50
Novig — Deposit $10, Get $25 in Trade Credits
Novig
NovigDeposit $10, Get $25 in Trade Credits
$25
Underdog — First-Time Deposit Match + Keep Your $1,000,000
Underdog
UnderdogFirst-Time Deposit Match + Keep Your $1,000,000
$1,000,000
Onyx Odds — Spend $10, Get $111 in Bonus Picks
Onyx Odds
Onyx OddsSpend $10, Get $111 in Bonus Picks
$111
Bet365 — Bet $10, Get $200 in Bonus Bets, Win or Lose
Bet365
Bet365Bet $10, Get $200 in Bonus Bets, Win or Lose
$200
Fanatics — Bet $20, Get $350 in FanCash
Fanatics
FanaticsBet $20, Get $350 in FanCash
$350
BetMGM — Get Up to $1500 in Bonus Bets if your First Bet Does Not Win
BetMGM
BetMGMGet Up to $1500 in Bonus Bets if your First Bet Does Not Win
$1,500
ProphetX — Trade $50, Get $75
ProphetX
ProphetXTrade $50, Get $75
$75
Rebet — Get a 100% Deposit Match up to $100
Rebet
RebetGet a 100% Deposit Match up to $100
$100
FanDuel — Bet $5, Get $250 in Bet Reset Tokens over 5 Days
FanDuel
FanDuelBet $5, Get $250 in Bet Reset Tokens over 5 Days
$250
When you click our links to visit an operator and sign up, we may receive a commission at no extra cost to you. This financial relationship helps support our site.
Pickswise
Get exclusive 
free sports picks
to your email
subscriber 1
subscriber 2
subscriber 3
18K users have
already subscribed
Enter your email address
By signing up you agree to our terms and privacy