Pickswise
Illinois
Sep 2612:00 PM
Ohio State
DetailsPicks1AnalysisBest BetsParlays

Illinois vs Ohio State Prediction, Odds and NCAAF Picks for Saturday, 09/26/26

Illinois
Ohio State
IllinoisOhio State
College FootballSat, Sep 2612:00 PM
Point Spread Pick

The Illinois Fighting Illini will hit the road for the first time this weekend when they travel to Columbus to play the Ohio State Buckeyes, which will also mark the opening of their conference schedule. The Illini are 2-1 SU and 1-2 ATS through three games, including an outright loss to Duke at home as a -6.5 favorite. Meanwhile, Ohio State is 2-1 SU and 3-0 ATS after letting their opening-week game against Texas slip away on the road in Austin. In two home games, they’ve put up an average of 57.5 points per game against two MAC teams. 

Despite facing a strength of schedule that ranks 115th per Sagarin, the Fighting Illini rank 86th in yards per play allowed against FBS opponents, while they are 95th in havoc generated, 105th in PPA per play allowed, 101st on standard downs PPA allowed and 100th or worse in both rush and pass explosiveness allowed outside of garbage time. That’s not quite a recipe for success against an elite Ohio State offense led by quarterback Julian Sayin, wide receiver Jeremiah Smith and running back Bo Jackson. 

I’m acting under the impression that Illinois has to score in the 20s to have a chance at covering this number, and I don’t have much faith in that happening considering ECU transfer quarterback Katin Houser will be playing this game behind an offensive line composed mostly of non-FBS transfers. He previously was a Big Ten quarterback at Michigan State, where he made 14 turnover-worthy plays and just four big-time throws in 214 dropbacks in 2023. Obviously, he’s more experienced now, but he didn’t see any defenses close to the strength of Ohio State’s as a two-year starter at ECU, and he didn’t always perform well against the better defenses he saw. 

So far this season, UAB outgained Illinois 413-332 in Week 1, while they converted 10 of 19 third downs. The next week, Illinois allowed Duke to rush for nearly five yards per carry even though everyone knew running back Nate Sheppard was going to touch the ball more often than not. Plus, Walker Eget threw three touchdowns against this secondary, which sits 80th in PPA per pass allowed and 95th in passing success rate allowed. With those performances on tape, I have a hard time seeing them offer much resistance against the Buckeyes. 

Under Ryan Day, the Buckeyes have won and covered all but one Big Ten opener, and the lone non-cover was on the road. They covered their Big Ten home opener that year. Expect a focused effort from the Buckeyes, and for them to steamroll an overmatched Illini squad that, so far, has been a far cry from what we’re used to seeing from a Brett Bielema team.

Illinois vs Ohio State prediction: Ohio State -27 (-110) available at time of publishing. Playable to -28 (-105). 

Exclusive Offers
See all
Polymarket — Deposit $10, Get a $50 Trading Bonus
Polymarket
PolymarketDeposit $10, Get a $50 Trading Bonus
$50
Novig — Deposit $10, Get $25 in Trade Credits
Novig
NovigDeposit $10, Get $25 in Trade Credits
$25
Underdog — First-Time Deposit Match + Keep Your $1,000,000
Underdog
UnderdogFirst-Time Deposit Match + Keep Your $1,000,000
$1,000,000
Onyx Odds — Spend $10, Get $111 in Bonus Picks
Onyx Odds
Onyx OddsSpend $10, Get $111 in Bonus Picks
$111
Bet365 — Bet $10, Get $200 in Bonus Bets, Win or Lose
Bet365
Bet365Bet $10, Get $200 in Bonus Bets, Win or Lose
$200
Fanatics — Bet $20, Get $350 in FanCash
Fanatics
FanaticsBet $20, Get $350 in FanCash
$350
BetMGM — Get Up to $1500 in Bonus Bets if your First Bet Does Not Win
BetMGM
BetMGMGet Up to $1500 in Bonus Bets if your First Bet Does Not Win
$1,500
ProphetX — Trade $50, Get $75
ProphetX
ProphetXTrade $50, Get $75
$75
Rebet — Get a 100% Deposit Match up to $100
Rebet
RebetGet a 100% Deposit Match up to $100
$100
FanDuel — Bet $5, Get $250 in Bet Reset Tokens over 5 Days
FanDuel
FanDuelBet $5, Get $250 in Bet Reset Tokens over 5 Days
$250
When you click our links to visit an operator and sign up, we may receive a commission at no extra cost to you. This financial relationship helps support our site.
Pickswise
Get exclusive 
free sports picks
to your email
subscriber 1
subscriber 2
subscriber 3
18K users have
already subscribed
Enter your email address
By signing up you agree to our terms and privacy