Pickswise
Cleveland Guardians82-75, 41-35
3–2
FinalFenway Park, Boston
BOS
Boston Red Sox84-73, 38-38
Details1PicksAnalysisBest BetsParlays

Cleveland Guardians vs BOS Prediction, Odds and MLB Picks for Tuesday, 09/22/26

🔥 Win Probability

48.7%
Win probability chart
BOS
51.3%BOS

Probable Pitchers

Pitchers
BOS
BOS
Parker MessickSP, #77
Parker Messick
vs
Payton Tolle
Payton TolleSP, #70
PLAYERW-LERAWHIPIPHKBBHR
P. Messick12-92.551.04183.11431914817
P. Tolle9-63.031.10148.21231714015

Season Series

Current SeriesCLE leads series 1-0
Sep 22
3
@
BOS
BOS2
Final
Sep 23
-
@
BOS
BOS-
9/23
Sep 24
-
@
BOS
BOS-
9/24
Regular Season SeriesSeries tied 2-2
May 29
BOS
BOS3
@
4
Final
May 30
BOS
BOS9
@
1
Final
May 31
BOS
BOS9
@
4
Final
Sep 22
3
@
BOS
BOS2
Final
Sep 23
-
@
BOS
BOS-
9/23
Sep 24
-
@
BOS
BOS-
9/24

Injury Report

BOS
BOS
PlayerPosInjuryReturn
T. Houck
SPRight ElbowSep 21
A. Chapman
RP LatSep 21
J. Oviedo
SPRight ElbowSep 21
C. Rafaela
CFRight QuadricepsSep 21
C. Mead
3BLeft WristSep 21
Cleveland Guardians
PlayerPosInjuryReturn
C. Holderman
RPRight WristSep 21
R. Hoskins
1BBackSep 21
S. Armstrong
RPLeft CalfSep 22

Standings

2026 American League Central Standings

TeamWLGBSTRKPCT
Cleveland8275-W6.522
Chicago80761.5W2.513
Detroit74848.5L1.468
Minnesota73849L1.465
Kansas City678914.5L4.429

2026 American League East Standings

TeamWLGBSTRKPCT
Tampa Bay9561-L1.609
New York90665W1.577
Boston847311.5L3.535
Toronto778018.5L1.490
Baltimore768119.5W1.484