MLS Best Bets for August 22: Top Picks, Predictions & Odds for Saturday's Matches
The 2026 MLS season continues this weekend with a strong 13-game slate on Saturday, August 21, before a couple more games complete the set on Sunday. We have a ton of crunch clashes to get excited for, and you can get our expert MLS picks for all 15 matches. But for now, let's break down our 3 MLS best bets for Saturday.
MLS best bet: Inter Miami vs Toronto FC Under 3.5 Goals (+105)
Odds available at BetMGM at time of publishing. Playable to -110.
There might not be too much action in this one and the recommended bet is to go under the goals. Three of the last four MLS matches between Inter Miami and Toronto FC have stayed under 2.5 goals, so getting under 3.5 at plus-money odds looks a gift.
Get MLS stats, trends and more for our expert's 5-star Inter Miami vs Toronto FC prediction
MLS best bet: Los Angeles FC vs Portland Timbers Under 3.5 Goals (-140)
Odds available at DraftKings Sportsbook at time of publishing. Playable to -150.
Under 2.5 goals looks the best bet when Los Angeles FC host the Portland Timbers at BMO Stadium. LAFC have conceded just one goal per game on average this season, and there have been under 2.5 goals in their last three MLS matches.
Read the full analysis of our LAFC vs Portland Timbers prediction
MLS best bet: Chicago Fire ML over New York Red Bulls (+130)
Odds available at FanDuel Sportsbook at time of publishing. Playable to +110.
Take Chicago Fire to beat an out-of-form New York Red Bulls at Sports Illustrated Stadium. Chicago Fire's strong attack takes on a leaky Red Bulls defense, with the visitors having scored two goals or more in three MLS games in a row. New York are leaking goals.
Don't miss our full New York Red Bulls vs Chicago Fire prediction for Saturday's MLS matchup
MLS predictions for Saturday, August 22
Want even more MLS predictions? Check out our expert picks for all 15 games this weekend below!
- Charlotte FC vs DC United prediction
- FC Cincinnati vs Seattle Sounders prediction
- CF Montreal vs LA Galaxy prediction
- Inter Miami vs Toronto FC prediction
- Orlando City vs Real Salt Lake prediction
- New York Red Bulls vs Chicago Fire prediction
- Austin FC vs Philadelphia Union prediction
- St. Louis City vs Houston Dynamo prediction
- Nashville SC vs Columbus Crew prediction
- FC Dallas vs Vancouver Whitecaps prediction
- San Diego FC vs Colorado Rapids prediction
- Los Angeles FC vs Portland Timbers prediction
- San Jose Earthquakes vs Minnesota United prediction
- New England Revolution vs New York City FC prediction
- Atlanta United vs Sporting KC prediction
