Friday cross-sport parlay: 4-team multi-sport parlay at +1303 odds, including today's MLB, MLS, and College Football picks and predictions

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Matthew Lowrimore


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Matthew has been with Pickswise for a while now, covering a wide variety of sports. His main passions are college football and UFC, and those are the sports he has covered the most. Matthew uses a variety of methods to handicap games, including stats, trends, injuries, and situational factors. His goal is to consistently give out winners and will put in the research to try and achieve this. For Matt Lowrimore media enquiries, please email
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We have put together a 4-pick cross-sport parlay that will take you right through Friday, including picks from the MLB, MLS and college football. One pick is taken from each sport with a second pick from College Football. A winning ticket would give us a very nice payout with odds of +1303 at DraftKings Sportsbook.

Let’s break down each of these plays.

College Football pick today: UTSA Roadrunners -4.5 over Middle Tennessee Blue Raiders (-110), 7:30 pm ET

In what could be the biggest letdown spot of the week, Middle Tennessee is a team I’m looking to fade on Friday. The Blue Raiders just knocked off Miami on the road as 3-touchdown underdogs, and now return home for a date with UTSA. This is almost the perfect scenario for the Roadrunners to start Conference USA play and presents a great “sell high” spot for their opponent.

UTSA’s offense is averaging more yards per play than the Blue Raiders and the Roadrunners have also been far more efficient on 3rd downs, converting at nearly a 59% clip. UTSA has been an excellent road team under Jeff Traylor, posting a 13-5 ATS record in its last 18 road games. The Roadrunners are also 7-3 against the number in their last 10 conference games. For that reason, backing UTSA will be the play tonight.

Be sure to check out our full UTSA Roadrunners vs Middle Tennessee Blue Raiders predictions

MLS pick today: Toronto FC ML over Inter Miami CF (+110), 7:30 pm ET

Tonight we will see Toronto FC host Inter Miami CF at BMO Field. Head-to-head this season, Inter Miami CF defeated Toronto FC 2-1 back in August. At this point in the season, Toronto don’t have the pressure of making a playoff push, and they now can relish the spoiler role.
On top of that, Miami road play has been less than impressive this year, and they are also finding a hard time registering goals away from home, averaging 0.75 goals per match. For that reason, backing Toronto to collect all 3 points tonight will be the play.

Be sure to check out our full Inter Miami CF vs Toronto FC predictions

MLB pick today: Pittsburgh Pirates vs St. Louis Cardinals – Over 7 runs (-120), 8:15 pm ET

High totals have been a theme in the season series between the Pirates and Cardinals. The over/under record this season is 8-3-2. The total has gone over in 6 of the last 8 matchups and the average game total this season is 10.3.

Pittsburgh has scored a respectable 4.5 runs per game over their last 10, and appears capable right now of doing their part in taking a total over. On the flip side, the Cardinals have averaged over 6 runs per game against the Pirates this season. Any time they play Pittsburgh is a good opportunity for run production, therefore backing the over looks to be the best play tonight.

Be sure to check out our full Pittsburgh Pirates vs St. Louis Cardinals predictions

College Football pick today: Washington Huskies -3 over UCLA Bruins (-110), 10:30 pm ET

The Washington Huskies have started the season with a perfect 4-0 record and find themselves ranked in the top 15 of the AP Poll. Much to the chagrin of Indiana fans, head coach Kalen DeBoer and quarterback Michael Penix Jr seem to be picking up right where they left off in Bloomington – as the Huskies have been quite good offensively.

While this is Washington’s first game away from home, the Rose Bowl has not been much of a home-field advantage for the Bruins. Maybe UCLA fans will show up for a conference home game against a ranked opponent, but in any case, this does not appear to be a daunting road test for the Huskies. Take Washington to win and cover tonight.

Be sure to check out our full Washington Huskies vs UCLA Bruins predictions

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