Week 10 of the 2025 NFL regular season is on the immediate horizon, and it should be entertaining – headlined by a couple of big primetime matchups. The lineup begins with a Thursday Night Football showdown in the AFC West between the Raiders and Broncos. Later in the week we have Falcons vs Colts in Berlin, Steelers vs Chargers on Sunday Night Football and Eagles vs Packers on Monday Night Football.
Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week – and throughout the entire season. Also don’t miss the NFL best bets page for our top picks. For now, let’s break down the NFL Week 10 opening lines and give our best early bet to make.
NFL Week 10 opening lines and odds
Odds available at FanDuel Sportsbook at time of publishing
- Las Vegas Raiders +9.5 (-110) vs Denver Broncos -9.5 (-110) – Thursday Night Football
- Atlanta Falcons +6.5 (-110) vs Indianapolis Colts -6.5 (-110) – NFL Berlin Game
- New York Giants +3.5 (-115) vs Chicago Bears -3.5 (-105)
- Buffalo Bills -9.5 (-105) vs Miami Dolphins +9.5 (-115)
- Baltimore Ravens -3.5 (-110) vs Minnesota Vikings +3.5 (-110)
- Cleveland Browns +1.5 (-105) vs New York Jets -1.5 (-115)
- New England Patriots +2.5 (-110) vs Tampa Bay Buccaneers -2.5 (-110)
- New Orleans Saints +4.5 (-105) vs Carolina Panthers -4.5 (-115)
- Jacksonville Jaguars +1.5 (-115) vs Houston Texans -1.5 (-105)
- Arizona Cardinals N/A (-105) vs Seattle Seahawks N/A
- Los Angeles Rams -3 (-118) vs San Francisco 49ers +3 (-104)
- Detroit Lions N/A vs Washington Commanders N/A
- Pittsburgh Steelers +3 (-104) vs Los Angeles Chargers -3 (-118) – Sunday Night Football
- Philadelphia Eagles +2.5 (-110) vs Green Bay Packers -2.5 (-110) – Monday Night Football
Best bet for NFL Week 10: Carolina Panthers -4.5 over New Orleans Saints (-115)
It’s hard to describe just how bad the Saints are. They are 1-8 and their only win is thanks to the Giants losing the turnover battle 5 to 0 in Week 5. All 8 of New Orleans’ losses have come by at least 5 points. Now we’re asking head coach Kellen Moore’s crew to stay closer than that against a team that just went into Green Bay and beat the Packers?!?! It’s a no from me.
Amazingly enough, the Saints have actually gotten worse in recent weeks. They have not come within 12 points since Week 6 and their 2 most recent setbacks are by a combined margin of 57-13. Tyler Shough got his first NFL start on Sunday and the offense was predictably inept during a 34-10 rout at the hands of the Rams. Shough threw for 176 yards with 1 TD and 1 INT. The Panthers have won 4 of their last 5 games and their only home loss this season is against the Bills. Let’s back Carolina to not only win but also cover with ease.
We’ll have NFL picks for every game in Week 10!
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