Week 11 of the 2025 NFL regular season is on the immediate horizon. It should be a fun one, although it may take a while to get going. We have to watch the Jets play on Thursday Night Football (although they have won 2 straight!) and then Spanish fans of American football will be forced to sit through a Madrid matchup between the Commanders and Dolphins. After that, though, we get Bucs vs Bills, Seahawks vs Rams, Chiefs vs Broncos and Lions vs Eagles on Sunday Night Football.
Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week – and throughout the entire season. Also, don’t miss the NFL best bets page for our top picks. For now, let’s break down the NFL Week 11 opening lines and give our best early bet to make.
NFL Week 11 opening lines and odds
Odds available at DraftKings Sportsbook at time of publishing
- New York Jets +10.5 (-110) vs New England Patriots -10.5 (-110) – Thursday Night Football
- Washington Commanders +2.5 (-115) vs Miami Dolphins -6.5 (-105) – NFL Madrid Game
- Carolina Panthers +3.5 (-105) vs Atlanta Falcons -3.5 (-115)
- Tampa Bay Buccaneers +5.5 (-112) vs Buffalo Bills -5.5 (-108)
- Houston Texans -8.5 (-110) vs Tennessee Titans +8.5 (-110)
- Chicago Bears +3 (-115) vs Minnesota Vikings -3 (-105)
- Green Bay Packers -7.5 (-110) vs New York Giants +7.5 (-110)
- Cincinnati Bengals +5.5 (-110) vs Pittsburgh Steelers -5.5 (-110)
- Los Angeles Chargers -3 (-102) vs Jacksonville Jaguars +3 (-118)
- Seattle Seahawks +2.5 (-110) vs Los Angeles Rams -2.5 (-110)
- San Francisco 49ers -2.5 (-110) vs Arizona Cardinals +2.5 (-110)
- Baltimore Ravens -8.5 (-110) vs Cleveland Browns +8.5 (-110)
- Detroit Lions +1.5 (-120) vs Philadelphia Eagles -1.5 (+100) – Sunday Night Football
- Dallas Cowboys -3 (-115) vs Las Vegas Raiders +3 (-105) – Monday Night Football
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Best bet for NFL Week 11: Cincinnati Bengals +5.5 over Pittsburgh Steelers (-110)
This is a fantastic spot for the Bengals. They are coming off a bye, whereas the Steelers just got beat up by the Chargers on Sunday Night Football in Week 10. Cincinnati has not lost by more than 5 points since Week 6 and I expect that streak to continue. After all, Joe Flacco and company just defeated Pittsburgh 33-31 in their first head-to-head showdown of the season on October 16. Flacco is on an absolute roll, with an 11-to-2 touchdown-to-interception ratio in 4 games since being traded from Cleveland. Steelers QB Aaron Rodgers, on the other hand, has been picked off 4 times in the last 4 outings – including twice by the Bolts on SNF.
With some obvious exceptions every now and then, rivalry matchups in the AFC North are often hard-nosed, competitive contests regardless of any discrepancies in talent. I will rarely give more than 3 points, and there is no way I’m giving 5.5 in this particular game.
We’ll have NFL picks for every game in Week 11!
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