NFL Odds for Week 13: Opening Betting Lines, Spreads & Totals – Texans defense preys on vulnerable Colts

Week 13 of the 2025 NFL regular season is on the immediate horizon. It is without question one of the most fun weeks of the year – a smorgasbord of football and food. Thanksgiving brings us 3 games on Thursday: Packers vs Lions, Chiefs vs Cowboys and Bengals vs Ravens. The Bears and Eagles will collide on Black Friday before the Sunday slate offers Texans vs Colts and Bills vs Steelers. 

Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week – and throughout the entire season. Also don’t miss the NFL best bets page for our top picks. For now, let’s break down the NFL Week 13 opening lines and give our best early bet to make.  

NFL Week 13 opening lines and odds  

Odds available at DraftKings Sportsbook at time of publishing  

• Green Bay Packers +3 (-120) vs Detroit Lions -3 (+100) – Thanksgiving  

• Kansas City Chiefs -3.5 (-110) vs Dallas Cowboys +3.5 (-110) – Thanksgiving 

• Cincinnati Bengals +7.5 (-110) vs Baltimore Ravens -7.5 (-110) – Thanksgiving 

• Chicago Bears +7 (-110) vs Philadelphia Eagles -7 (-110) – Black Friday 

• Atlanta Falcons -2.5 (-110) vs New York Jets +2.5 (-110) 

• San Francisco 49ers -6 (-110) vs Cleveland Browns +6 (-110) 

• Jacksonville Jaguars -7 (-110) vs Tennessee Titans +7 (-110)    

• Houston Texans +3.5 (-115) vs Indianapolis Colts -3.5 (-105) 

• New Orleans Saints +5.5 (-110) vs Miami Dolphins -5.5 (-110) 

• Arizona Cardinals N/A vs Tampa Bay Buccaneers N/A

• Los Angeles Rams N/A vs Carolina Panthers N/A

• Minnesota Vikings +8.5 (-110) vs Seattle Seahawks -8.5 (-110) 

• Buffalo Bills -4.5 (-105) vs Pittsburgh Steelers +4.5 (-115) 

• Las Vegas Raiders +10 (-110) vs Los Angeles Chargers -10 (-110) 

• Denver Broncos -6.5 (-115) vs Washington Commanders +6.5 (-105) – Sunday Night Football 

• New York Giants +7.5 (-110) vs New England Patriots -7.5 (-110) – Monday Night Football 

Best bet for NFL Week 13: Houston Texans +3.5 over Indianapolis Colts (-105)  

There is no way I’m giving more than a field goal in a division-rivalry game between the Texans and Colts. And I’m definitely not doing it when Houston – and its absolutely ferocious defense – is the side catching 3.5 points. Head coach DeMeco Ryans’ squad turned in a dominant defensive performance during a 23-19 victory over Buffalo this past Thursday night. The Texans forced 3 turnovers (2 Josh Allen interceptions), held the Bills to 4.9 yards per play and sacked Allen an absurd 8 times for a total of 70 lost yards.

Now the Texans are playing on a mini-bye following their Thursday Night Football exploits. Whereas Houston is well rested and rolling (it is 6-2 in its last 8 games since beginning the season 0-3), Indianapolis is coming off a tough loss to Kansas City. Prior to that result, the Colts needed overtime to get past the lowly Falcons in Berlin. Daniel Jones was playing great earlier this year, but he has come back down to Earth over the past 3 outings. Jones vs this Houston pass rush spells serious trouble for the home side on Sunday afternoon. 

We’ll have NFL picks for every game in Week 13!