Week 15 of the 2025 NFL regular season is on the immediate horizon. And it’s a busy one. Byes are over, so all 32 teams will be taking the field. Yes, we have 16 football games on this mid-December menu – including 14 on Sunday. Week 15 kicks off with a showdown in the NFC South between the Falcons and Buccaneers. Also on the schedule are Ravens vs Bengals, Chargers vs Chiefs, Bills vs Patriots, Packers vs Broncos and Lions vs Rams.
Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week – and throughout the entire season. Also don’t miss the NFL best bets page for our top picks. For now, let’s break down the NFL Week 15 opening lines and give our best early bet to make.
NFL Week 15 opening lines and odds
Odds available at DraftKings Sportsbook at time of publishing
- Atlanta Falcons +4.5 (-105) vs Tampa Bay Buccaneers -4.5 (-115) – Thursday Night Football
- Cleveland Browns +7 (-105) vs Chicago Bears -7 (-115)
- Baltimore Ravens -1.5 (-115) vs Cincinnati Bengals +1.5 (-105)
- Los Angeles Chargers N/A vs Kansas City Chiefs N/A
- Buffalo Bills -1.5 (+100) vs New England Patriots +1.5 (-120)
- Washington Commanders +1.5 (-110) vs New York Giants -1.5 (-110)
- Las Vegas Raiders +13.5 (-115) vs Philadelphia Eagles -13.5 (-105)
- New York Jets +12.5 (-110) vs Jacksonville Jaguars -12.5 (-110)
- Arizona Cardinals N/A vs Houston Texans N/A
- Green Bay Packers -1.5 (-110) vs Denver Broncos +1.5 (-110)
- Detroit Lions +4.5 (-110) vs Los Angeles Rams -4.5 (-110)
- Carolina Panthers -2.5 (-110) vs New Orleans Saints +2.5 (-110)
- Tennessee Titans +13.5 (-118) vs San Francisco 49ers -13.5 (-102)
- Indianapolis Colts +10.5 (-110) vs Seattle Seahawks -10.5 (-110)
- Minnesota Vikings +6 vs Dallas Cowboys -6 (-110) – Sunday Night Football
- Miami Dolphins +3 (+100) vs Pittsburgh Steelers -3 (-120) – Monday Night Football
Best bet for NFL Week 15: Carolina Panthers -2.5 over New Orleans Saints (-110)
This is a fantastic situational spot for the Panthers. They are coming off a bye and they are facing an opponent that just bagged its biggest win of the season. The Saints’ stock is suddenly inflated following what can only be considered a fluke victory at Tampa Bay. New Orleans’ season-long sample size confirms that this is a far inferior team compared to what was on display in Week 14. And it’s not like the Bucs are that good. They are in shambles, in fact – their record since a Week 9 bye is 1-4. The Saints gained only 260 yards of total offense but still managed to prevail 24-20. Finally, playing at home is not exactly an advantage for head coach Kellen Moore’s crew. It is 1-5 at the Mercedes-Benz Dome compared to 2-5 on the road.
The Panthers are 6-3 in their last 9 games and find themselves tied atop the NFC South with the Bucs. Carolina most recently knocked off the Rams in Week 13 – one of the most surprising results of this entire 2025 campaign. Bryce Young has compiled a 3-to-0 touchdown-to-interception ratio in 2 of his last 3 outings. The Alabama product has tossed at least 3 TD passes in 4 games so far this year. With Young heating up and New Orleans being priced like a decent team rather than one of the worst in the league, give me Carolina to win and cover.
We’ll have NFL picks for every game in Week 15!
Click here to add us to your Google preferred sources and never miss a story
