Week 17 of the 2025 NFL regular season is on the immediate horizon. It’s another busy one, too, spread out across many days in celebration of the Christmas festivities. We have 16 football games on this late-December menu – including 3 on Thursday (Christmas) and 2 on Saturday. On the Week 17 schedule are Texans vs Chargers, Jaguars vs Colts, Seahawks vs Panthers, Eagles vs Bills and Bears vs 49ers.
Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week – and throughout the entire season. Also don’t miss the NFL best bets page for our top picks. For now, let’s break down the NFL Week 17 opening lines and give our best early bet to make.
NFL Week 17 opening lines and odds
Odds available at DraftKings Sportsbook at time of publishing
- Dallas Cowboys -6 (-108) vs Washington Commanders +6 (-112) – Christmas
- Detroit Lions -6 (-112) vs Minnesota Vikings +6 (-108) – Christmas
- Denver Broncos -12.5 (-120) vs Kansas City Chiefs +12.5 (+100) – Christmas
- Houston Texans +2.5 (-115) vs Los Angeles Chargers -2.5 (-105) – Saturday
- Baltimore Ravens +2.5 (-110) vs Green Bay Packers -2.5 (-110) – Saturday
- Seattle Seahawks -7.5 (-105) vs Carolina Panthers +7.5 (-115)
- Arizona Cardinals +7 (-110) vs Cincinnati Bengals -7 (-110)
- Pittsburgh Steelers -4.5 (-108) vs Cleveland Browns +4.5 (-112)
- New England Patriots -13.5 (-108) vs New York Jets +13.5 (-112)
- Tampa Bay Buccaneers -5.5 (-110) vs Miami Dolphins +5.5 (-110)
- New Orleans Saints -2.5 (-115) vs Tennessee Titans +2.5 (-105)
- Jacksonville Jaguars -7 (-105) vs Indianapolis Colts +7 (-115)
- New York Giants -1.5 (-105) vs Las Vegas Raiders +1.5 (-115)
- Philadelphia Eagles +2.5 (-110) vs Buffalo Bills -2.5 (-112)
- Chicago Bears +2.5 (+102) vs San Francisco 49ers -2.5 (-122) – Sunday Night Football
- Los Angeles Rams -8.5 (-105) vs Atlanta Falcons +8.5 (-115) – Monday Night Football
Best bet for NFL Week 17: Tampa Bay Buccaneers vs Miami Dolphins Under 46.5 (-110)
The Tua Tagovailoa era is over in Miami – or at least that appears to be the case. At the very least, Tagovailoa’s season is over. The left-hander was benched following Week 15 and Quinn Ewers replaced him this past Sunday. Ewers was unspectacular at best during a home loss to Cincinnati this past weekend. The Texas product did not throw a touchdown pass and was picked off twice. The Dolphins had 14 points with more than 6 minutes remaining in the first half, but they did not score again until garbage time against a defense that is the absolute worst in football.
Ewers has a much tougher test on his hands against Tampa Bay. The Bucs’ pass defense is poor, but that is not exactly how Miami moves the ball down the field – especially not with Ewers under center. Tampa Bay is very good against the run, ranking seventh in the league in that department. Count on the visitors stacking the box and doing its best to take De’Von Achane out of the equation. On the other side of the ball, the Bucs’ second-half collapse is due in part to a struggling offense. Baker Mayfield has thrown 6 interceptions in the past 6 games; he threw 2 in the first 9.
We’ll have NFL picks for every game in Week 17!
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