NFL Odds for Week 7: Opening Betting Lines, Spreads & Totals – Patriots, Titans going in wildly different directions

Week 7 of the 2025 NFL regular season is on the immediate horizon, and it is shaping up to a fun one. The lineup begins with a Thursday Night Football showdown in the AFC North between the Steelers and Bengals. Primetime games later in the week feature the Falcons, 49ers, Buccaneers, Lions and Seahawks, while the London Games continue with Rams vs Jaguars. 

Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week – and throughout the entire season. Also make sure to check out our NFL best bets page for our top picks. For now, let’s break down the NFL Week 7 opening lines and give our best early bet to make.  

NFL Week 7 opening lines and odds  

Odds available at DraftKings Sportsbook at time of publishing  

• Pittsburgh Steelers -5.5 (-112) vs Cincinnati Bengals +5.5 (-108) – Thursday Night Football  

• Los Angeles Rams -3 (-118) vs Jacksonville Jaguars +3 (-102) – NFL London Games 

• New Orleans Saints N/A vs Chicago Bears N/A 

• Philadelphia Eagles -2.5 (-110) vs Minnesota Vikings +2.5 (-112)  

• New England Patriots -7 (-115) vs Tennessee Titans +7 (-105) 

• Carolina Panthers -1.5 (-102) vs New York Jets +1.5 (-118) 

• Las Vegas Raiders +11.5 (-108) vs Kansas City Chiefs -11.5 (-112)    

• Miami Dolphins +2.5 (-112) vs Cleveland Browns -2.5 (-108) 

• New York Giants +7 (-110) vs Denver Broncos -7 (-110) 

• Indianapolis Colts +1.5 (-112) vs Los Angeles Chargers -1.5 (-108) 

• Green Bay Packers -6.5 (-112) vs Arizona Cardinals +6.5 (-108) 

• Washington Commanders N/A vs Dallas Cowboys N/A 

• Atlanta Falcons N/A vs San Francisco 49ers N/A – Sunday Night Football 

• Tampa Bay Buccaneers +4.5 (-108) vs Detroit Lions -4.5 (-112) – Monday Night Football 

• Houston Texans +3.5 (-118) vs Seattle Seahawks -3.5 (-102) – Monday Night Football  

Best bet for NFL Week 7: New England Patriots -7 over Tennessee Titans (-115)  

The Titans just fired head coach Bill Callahan – and for good reason. This is the worst team in the entire NFL…yes, even worse than the Jets. Tennessee is 1-5 and its only win is a miracle (“fluke” would probably be an even more accurate description) fourth-quarter comeback from 15 points down against Arizona, made possible by Cardinals running back Emari Demarcado dropping the ball before going into the endzone followed by one of the luckiest touchdowns in football history after the Cardinals fumbled an interception. 

Teams can sometimes galvanize around an interim head coach, but that’s usually when they have a chance to really turn around the season. That obviously isn’t the case with the Titans. Even they know that this is a rebuilding process that will require many years. Now they are being asked to compete with a team that went into Orchard Park and beat the Bills in Week 5? The Patriots are 4-2, have won 3 in a row, and Drake Maye looks like the real deal at quarterback. Moreover, they are 3-0 on the road. It’s not like Tennessee has any kind of significant home-field advantage, either, so New England should win this game by more than a touchdown. 

We’ll have NFL picks for every game in Week 7!