NFL Odds for Week 9: Opening Betting Lines, Spreads & Totals – Colts prove (again) that they’re for real

Week 9 of the 2025 NFL regular season is on the immediate horizon, and it is shaping up to a fun one. The lineup begins with a Thursday Night Football showdown in the AFC between the Ravens and Dolphins. Primetime games later in the week feature the Seahawks, Commanders and Cowboys, while the biggest matchup on the entire slate pits the Chiefs against the Bills. 

Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week – and throughout the entire season. Also don’t miss the NFL best bets page for our top picks. For now, let’s break down the NFL Week 9 opening lines and give our best early bet to make.  

NFL Week 9 opening lines and odds  

Odds available at DraftKings Sportsbook at time of publishing  

• Baltimore Ravens -7.5 (-112) vs Miami Dolphins +7.5 (-108) – Thursday Night Football  

• Carolina Panthers +12.5 (-105) vs Green Bay Packers -12.5 (-115)  

• San Francisco 49ers -2.5 (-120) vs New York Giants +2.5 (+100) 

• Denver Broncos +1.5 (-110) vs Houston Texans -1.5 (-110)  

• Chicago Bears -2.5 (-110) vs Cincinnati Bengals +2.5 (-110) 

• Atlanta Falcons +5.5 (-110) vs New England Patriots -5.5 (-110) 

• Indianapolis Colts -3 (-115) vs Pittsburgh Steelers +3 (-105)    

• Minnesota Vikings +8.5 (-110) vs Detroit Lions -8.5 (-110) 

• Los Angeles Chargers -10 (-110) vs Tennessee Titans +10 (-110) 

• New Orleans Saints +13.5 (-105) vs Los Angeles Rams -13.5 (-115) 

• Jacksonville Jaguars -3 (-120) vs Las Vegas Raiders +3 (+100) 

• Kansas City Chiefs -1.5 (-105) vs Buffalo Bills +1.5 (-115) 

• Seattle Seahawks -3 (-118) vs Washington Commanders +3 (-102) – Sunday Night Football 

• Arizona Cardinals +2.5 (-102) vs Dallas Cowboys -2.5 (-118) – Monday Night Football 

Best bet for NFL Week 9: Indianapolis Colts -3 over Pittsburgh Steelers (-115)  

At this point in the season, the sample size is large enough to prove that the Colts are no fluke. They are 7-1 and their only loss has come on the road against the Rams in a game they really should have won. Five of Indianapolis’ victories have come by double-digits, including margins of 25, 21, 34 and 24. Daniel Jones’ resurgence is on course to be the stuff of legend.

The Steelers are only 3-point underdogs because they are playing at home, but what good has Acrisure Stadium done so far this season? Aaron Rodgers and company have already lost there twice – by 14 points to Seattle in Week 2 and by 10 to Green Bay this past Sunday. The Packers went on a 21-0 run in the fourth quarter before the Steelers scored a late meaningless touchdown. This is simply a tale of 2 teams going in different directions – and with a significant discrepancy in talent level. 

We’ll have NFL picks for every game in Week 9!