NFL Week 5 Opening Odds, Betting Lines, and spreads: Cowboys and 49ers star in primetime

Dallas Cowboys cornerback DaRon Bland (26) celebrates with teammates after intercepting a pass during the second half against the New England Patriots at AT&T Stadium.
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Lead MLB Writer for Pickswise. A Bostonian with a love for stats and baseball. Using knowledge and passion to find the right bet in MLB, NBA, NFL, and more. A lover of bold sports takes and sweat-free plus-odds picks. For Keith Schmelter media enquiries, please email

Heading into NFL Week 5, only two teams remain without a loss. The undefeated teams are the San Francisc0 49ers and the Philadelphia Eagles, who were also involved in last year’s NFC Championship game.

Most sportsbooks announced game lines for the next week on Sunday night, so here are the opening Week 5 lines. Make sure you keep checking our NFL predictions as we add our picks on the side and total for every game throughout the week. Our experts have been red hot, going 11-2-1 on sides and boasting a 5-0 NFL best bets record in Week 4.

NFL Week 5 opening lines and odds

Odds available at FanDuel Sportsbook at time of publishing.

Chicago Bears +5.5 (-105) vs Washington Commanders -5.5 (-110) – Thursday Night Football
Jacksonville Jaguars +5.5 (-115) vs Buffalo Bills -5.5 (-105)
Houston Texans +2.5 (-110) vs Atlanta Falcons -2.5 (-110)
Carolina Panthers +8.5 (-105) vs Detroit Lions -8.5 (-115)
Tennessee Titans -1.5 (-102) vs Indianapolis Colts +1.5 (-120)
New York Giants +9.5 (-105) vs Miami Dolphins -9.5 (-115)
Baltimore Ravens -3.5 (-105) vs Pittsburgh Steelers +3.5 (-115)
New Orleans Saints +1.5 (-115) vs New England Patriots -1.5 (-105)
Cincinnati Bengals -5.5 (-105) vs Arizona Cardinals +5.5 (-115)
Philadelphia Eagles -5.5 (-105) vs Los Angeles Rams +5.5 (-115)
Kansas City Chiefs -6 (-110) vs Minnesota Vikings +6 (-110)
New York Jets +2.5 (-105) vs Denver Broncos -2.5 (-115)
Dallas Cowboys +3.5 (-115) vs San Francisco 49ers -3.5 (-105) – Sunday Night Football
Green Bay Packers -1.5 (-104) vs Las Vegas Raiders +1.5 (-118) – Monday Night Football

Best early bet for NFL Week 5: 49ers -3.5 over Cowboys (-110)

In my opinion, the San Francisco 49ers are the best team in football. The Niners stayed perfect with a 35-16 win over the Cardinals in Week 4 in which Brock Purdy completed 20 of 21 attempts and Christian McCaffrey finished with 4 touchdowns. The game wasn’t expected to be close in the first place, but it was still impressive to see San Francisco grab the lead early and never look back. That means the 49ers have won by 23, 7, 18 and 19 points through 4 weeks. The Niners have yet to meet a team that could compete with them, and it won’t come in Week 5 either. Oddsmakers seem rather high on the Cowboys after their Week 4 win over the Patriots, but let’s be honest, the New England offense isn’t too dangerous. I would take the 49ers up to a touchdown, so their 3.5-point spread is a gift.

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