The 2025 NFL regular season is over, so the stage is finally set for playoff action. Earning first-round byes and home-field advantage until the Super Bowl are the Denver Broncos and Seattle Seahawks, while the other 12 playoff teams will take the field on Super Wild Card Weekend. And what a weekend it should be, with 2 games on Saturday, 3 on Sunday and a postseason instalment of Monday Night Football.
Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week, and throughout the entire playoffs, after our experts went 13-3 on sides and 9-7 on totals in Week 18 to secure +75.2 units of profit over the course of the 2025 NFL season! Also, find out our NFL best bets for our top picks. For now, let’s break down the NFL Super Wild Card Weekend opening lines and give our best early bet to make.
NFL Super Wild Card Weekend opening lines and odds
Odds available at DraftKings Sportsbook at time of publishing
- Los Angeles Rams -10 (-110) vs Carolina Panthers +10 (-110) – Saturday
- Green Bay Packers -1.5 (+100) vs Chicago Bears +1.5 (-120) – Saturday
- Buffalo Bills -1.5 (-102) vs Jacksonville Jaguars +1.5 (-118) – Sunday
- San Francisco 49ers +3.5 (-115) vs Philadelphia Eagles -3.5 (-105) – Sunday
- Los Angeles Chargers +3.5 (-110) vs New England Patriots -3.5 (-110) – Sunday Night Football
- Houston Texans -3 (-110) vs Pittsburgh Steelers +3 (-110) – Monday Night Football
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Best bet for Super Wild Card Weekend: Houston Texans -3 over Pittsburgh Steelers (-110)
Just how much parity is there in the NFL these days? Well, consider this: in 6 playoff games in the upcoming first round, 4 of the road teams are favored. That’s right; 4 wild-card teams are expected to defeat 4 division champions. In the case of Houston vs Pittsburgh, it’s not hard to figure out why. The Texans had too much ground to make up in the AFC South after starting 0-3 and then 3-5, but they have won 9 games in a row and boast the best defense in the entire NFL. I wouldn’t even be shocked if they went to the Super Bowl.
The Steelers won the moribund AFC North – in which the Ravens, Bengals and Browns were all complete disasters. Credit to head coach Mike Tomlin’s team for prevailing in a winner-take-all Sunday Night Football showdown against Baltimore, but – despite the outrageous entertainment – both teams looked awful and the Ravens should have won but missed a routine field goal as time expired.
Pittsburgh’s defense was mostly horrible on Sunday and it will have to be amazing in this particular matchup if the home team wants to have any chance. After all, Aaron Rodgers and the Steelers can’t be expected to score much. This is a rough spot for a 42-year-old quarterback going up against a defense that is ranked 1st overall, 2nd in scoring, 6th against the pass, 3rd in interceptions and 6th in sacks. Houston clobbered the Chargers 32-12 on Wild Card Weekend last year (albeit at home) and it should once again roll into the Divisional Round.
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