Opening college football betting lines, odds and spreads for Week 10 of the CFB season: Massive weekend ahead in the Big 12

Kansas State Wildcats quarterback Will Howard (18) scores a touchdown in the fourth quarter against the UCF Knights at Bill Snyder Family Football Stadium.
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Caleb Wilfinger


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Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email
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Nine weeks of the 2023 college football season are in the books, and what a season it’s been! We’ve certainly got eventful matchups every weekend, with plenty of upsets to keep fans entertained while also having enough chalk prevail to keep the top of the rankings loaded with traditional powerhouses. 

Now it’s time to turn our attention to Week 10. The slate is very solid from top to bottom, headlined by a massive game in the Pac-12 between Washington and USC, a clash of titans in the SEC between LSU and Alabama, plus a couple of important Big 12 matchups. The opening lines were released at most sportsbooks on Sunday, so let’s take a look at these openers and give our first impressions. 

NCAAF Week 10 opening lines and odds

Odds available at DraftKings Sportsbook at time of publishing.  

  • TCU +3 (-110) vs Texas Tech – Thursday, November 2
  • South Alabama +6 (-110) vs Troy – Thursday, November 2
  • Colorado State +7 (-110) vs Wyoming  – Friday, November 3
  • Ohio State -18.5 (-105) vs Rutgers – Saturday, November 4
  • Texas A&M +4.5 (-110) vs Ole Miss – Saturday, November 4
  • Oklahoma -6.5 (-110) vs Oklahoma State – Saturday, November 4
  • Arkansas +6.5 (-110) vs Florida – Saturday, November 4
  • Kansas State +7 (-110) vs Texas – Saturday, November 4
  • Arizona State +12.5 (-110) vs Utah – Saturday, November 4
  • James Madison -5.5 (-110) vs Georgia State – Saturday, November 4
  • Missouri +16.5 (-110) vs Georgia – Saturday, November 4
  • Notre Dame -3 (-110) vs Clemson – Saturday, November 4
  • Penn State -11.5 (-110) vs Maryland – Saturday, November 4
  • Iowa -6.5 (-110) vs Northwestern – Saturday, November 4
  • Florida State -21.5 (-110) vs Pittsburgh – Saturday, November 4
  • California +24 (-110) vs Oregon – Saturday, November 4
  • Kansas -1 (-110) vs Iowa State – Saturday, November 4
  • LSU +4.5 (-110) vs Alabama – Saturday, November 4
  • Washington -3 (-110) vs USC – Saturday, November 4
  • Boise State +3.5 (-110) vs Fresno State – Saturday, November 4
  • UCLA -1.5 (-110) vs Arizona – Saturday, November 4
  • Oregon State -12.5 (-110) vs Colorado – Saturday, November 4

We have college football picks and NCAAF predictions for all the big games this season!

Kansas State Wildcats +7 vs Texas Longhorns (-110)

I’ve been backing Kansas State heavily for the last 3 weeks and that won’t change here in what should be an excellent game in the Big 12 on Saturday. I’m betting that Chris Klieman will have his team extremely prepared for a matchup that could decide their conference fate. Ever since the combination of Will Howard and freshman standout Avery Johnson at quarterback has been implemented as a 2-headed monster, opposing defenses have been in a world of trouble. Kansas State has scored 38+ points in each of its last 3 games and I’d expect Collin Klien to go back to the well in a hostile environment.

On the other side, Texas will be without Quinn Ewers at quarterback for this game and while Malik Murphy showed promise in his first game under center, this Kansas State defense is an entirely different animal. I don’t anticipate points coming easily for a Texas team that has struggled with generating explosive plays in the passing game this season. It also helps that the Wildcats’ defense is one of the best in the nation against the run, as it should force Murphy to beat them through the air on crucial downs. Let’s grab the full touchdown while it’s still on the board.

Iowa State Cyclones ML over Kansas Jayhawks (-110)

This is one of the best spots of the entire weekend, as we’ll get to back an underrated Iowa State team against a Kansas team that is coming off one of its biggest wins in decades over then-No.6 Oklahoma last Saturday. From a handicapping perspective, there isn’t a better spot I’d want to sell high on the Jayhawks than as a short favorite/pick ’em against a team that is largely flying under the radar from a national perspective. The Cyclones are unheralded but in the midst of their best run of form this season, having won 3 straight games in October, 2 of which coming on the road. It may no longer be “Brocktober” in Des Moines but Matt Campbell is turning in one of his best coaching jobs in years. I don’t expect Jason Bean and company to be stopped entirely, but the Cyclones’ strong defense should force Bean into some more turnovers in what should be a close contest throughout.

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