Opening college football betting lines, odds and spreads for Week 7 of the CFB season: Showdown set in Seattle

Washington Huskies quarterback Michael Penix Jr.
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Caleb Wilfinger


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Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email
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Six weeks of the 2023 college football season are in the books, and what a season it’s been! We’ve certainly got eventful matchups every weekend, with plenty of upsets to keep fans entertained while also having enough chalk prevail to keep the top of the rankings loaded with traditional powerhouses. 

Now it’s time to turn our attention to Week 7. The slate is very solid from top to bottom, headlined by a massive game in the Pac-12, plus ranked matchups in the ACC, SEC and a nonconference tilt between USC and Notre Dame. The opening lines were released at most sportsbooks on Sunday, so let’s take a look at these openers and give our first impressions. 

NCAAF Week 7 opening lines and odds

Odds available at DraftKings Sportsbook at time of publishing.  

  • Tulane -3 (-110) vs Memphis – Friday, October 13 
  • Fresno State -7 (-110) vs Utah State – Friday, October 13 
  • Stanford +12.5 (-110) vs Colorado – Friday, October 13
  • Florida +2.5 (-110) vs South Carolina – Saturday, October 14
  • Missouri +2.5 (-110) vs Kentucky – Saturday, October 14
  • Arkansas +19 (-110) vs Alabama – Saturday, October 14
  • Georgia -32.5 (-110) vs Vanderbilt – Saturday, October 14
  • Ohio State -20.5 (-110) vs Purdue – Saturday, October 14
  • Iowa State +4 (-110) vs Cincinnati – Saturday, October 14
  • Indiana +34 (-110) vs Michigan – Saturday, October 14
  • Oregon +3 (-110) vs Washington – Saturday, October 14
  • Texas A&M +4 (-110) vs Tennessee – Saturday, October 14
  • Auburn +13 (-110) vs LSU – Saturday, October 14
  • Kansas -4 (-110) vs Oklahoma State – Saturday, October 14
  • Iowa +10 (-110) vs Wisconsin – Saturday, October 14
  • USC +2.5 (-110) vs Notre Dame – Saturday, October 14
  • Kansas State +1 (-110) vs Texas Tech – Saturday, October 14
  • Louisville -8.5 (-110) vs Pittsburgh – Saturday, October 14
  • UCLA +4.5 (-110) vs Oregon State – Saturday, October 14
  • NC State +3.5 (-110) vs Duke – Saturday, October 14
  • Arizona +9.5 (-110) vs Washington State – Saturday, October 14
  • UMass +42.5 (-110) vs Penn State – Saturday, October 14
  • Illinois +14 (-110) vs Maryland – Saturday, October 14

We have college football picks and NCAAF predictions for all the big games this season!

Washington Huskies -3 over Oregon Ducks (-110)

In what will undoubtedly be the biggest game of the week — certainly the one with the biggest College Football Playoff implications — the Washington Huskies will host the Oregon Ducks in a blockbuster matchup between the Pac-12’s best teams in Seattle. These teams are elite on offense, with both sides ranking near the top of the country in available yards gained and points per quality possession. However, Michael Penix Jr. and this Huskies offense have already proven that they can break down this Oregon defense through the air, having won in Autzen Stadium in a thriller last fall. I rate Washington slightly higher than Oregon on a neutral field, so I have no problem with laying the 3 points once I factor in home-field advantage. Let’s hope this one lives up to the billing.

Iowa Hawkeyes +10 vs Wisconsin Badgers (-110)

The biggest game in the Big Ten West to this point in the season features a pair of teams that don’t exactly set the world on fire offensively. Iowa is notorious at this point for putting forth a terrible offense and needing to be carried by its special teams and defense in order to win games. Thankfully for the Hawkeyes, this game against Wisconsin is not one where much offense is expected from either side. The Badgers have gone to a pass-heavy offensive system, but throwing the ball downfield is a lot harder on this experienced Iowa secondary. In fact, Wisconsin has best had success when the Badgers have run the ball at a consistent clip so far this season. Given that this total is 37.5 and continues to tick down, I’m not sure how you don’t take the double digits with the underdog here.

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