Pickswise
JAX
Jacksonville Jaguars
Oct 41:00 PMPaycor Stadium, Cincinnati
CIN
Cincinnati Bengals
DetailsPicks2AnalysisBest BetsParlays

JAX vs CIN Prediction, Odds and NFL Picks for Sunday, 10/04/26

JAX
CIN
Jacksonville JaguarsCincinnati Bengals
NFLSun, Oct 41:00 PM
Point Spread Pick

Both these AFC squads have jumped out to 2-1 starts, although each is off contrasting results last Sunday. Jacksonville crushed defending AFC champion New England 35-6, marking the second time the Jaguars have scored at least 34 points this season. The Jags sit second in the NFL in EPA/Rush, highlighted by RB Bhayshul Tuten rushing for at least 65 yards in all three games.

The Bengals held the Texans out of the end zone in a 20-6 victory in Week 2, but Steelers QB Aaron Rodgers threw three TD passes to help beat Cincinnati 30-27 last Sunday. Bengals QB Joe Burrow equaled his TD pass total from the first two weeks with three TDs against Pittsburgh, but the Bengals allowed 411 yards of offense in their first defeat.

The Bengals have won four consecutive matchups with Jacksonville since 2020, capped off by a 31-27 home triumph last season that Burrow left due to injury. Cincinnati’s offense is close to the middle of the pack in EPA/Rush (13th) and EPA/Pass (15th), while Burrow has posted the fifth-lowest aDOT (Average Depth of Target) among QBs that have started at least two games (6.4). The Bengals are allowing 287.0 passing yards per game, the third-most in the league. Jaguars QB Trevor Lawrence looks to take advantage as he seeks his first game with more than 245 passing yards. Let’s grab the points with Jacksonville to cash on the road for the first time.

Jaguars vs Bengals prediction: Jaguars +2.5 (+100) available at time of publishing. Playable at that number to -110.

JAX
CIN
Jacksonville JaguarsCincinnati Bengals
NFLSun, Oct 41:00 PM
Game Totals PickOver

Cincinnati has been hit-or-miss defensively through the first three games. Twice the Bengals have given up at least 27 points, while also limiting the Texans to six points on the road. In their opening week against Tampa Bay, the Bengals forced four turnovers, but have posted one takeaway in the last two games. The Jaguars have allowed the fewest points through the first three weeks with 36, highlighted by a 35-6 rout of New England last Sunday.

Jacksonville and Cincinnati met in Week 2 last season as the Bengals held on for a 31-27 win on a 49.5 total. This Sunday’s matchup will be the first total of at least 50 points for the Jags since their 27-24 Wild Card loss to the Bills on a 51.5 total.

Both teams have done a solid job limiting yards to opposing running backs. Jacksonville is allowing 57.7 yards per game and Cincinnati is yielding 68.3 yards to running backs, which are both in the top 10 in that category. That means these teams will look to air it out as Bengals WR Ja’Marr Chase has picked things up since a 12-yard performance in Week 1. In the past two games, Chase compiled 75 yards at Houston and 98 yards against Pittsburgh.

The Jags are allowing the third-lowest defensive Pass EPA, while facing teams ranked 16th, 23rd, and 26th (Bengals ranked 15th). Although Jacksonville has yielded the fewest points in the NFL, this has an opportunity to be a high-scoring affair in Cincinnati.

Jaguars vs Bengals prediction: Over 51.5 (-102) available at time of publishing. Playable to 52.5.

Exclusive Offers
See all
Underdog — Play $5, Get $100
Underdog
UnderdogPlay $5, Get $100
$100
Onyx Odds — Spend $10, Get $111 in Bonus Picks
Onyx Odds
Onyx OddsSpend $10, Get $111 in Bonus Picks
$111
Novig — Deposit $10, Get $50 in Trade Credits
Novig
NovigDeposit $10, Get $50 in Trade Credits
$50
Polymarket — Deposit $10, Get a $25 Trading Bonus
Polymarket
PolymarketDeposit $10, Get a $25 Trading Bonus
$25
Fanatics — Bet $20, Get $350 in FanCash
Fanatics
FanaticsBet $20, Get $350 in FanCash
$350
BetMGM — Get Up to $1500 in Bonus Bets if your First Bet Does Not Win
BetMGM
BetMGMGet Up to $1500 in Bonus Bets if your First Bet Does Not Win
$1,500
ProphetX — Trade $50, Get $75
ProphetX
ProphetXTrade $50, Get $75
$75
Rebet — Get a 100% Deposit Match up to $100
Rebet
RebetGet a 100% Deposit Match up to $100
$100
FanDuel — Bet $5, Get $250 in Bet Reset Tokens over 5 Days
FanDuel
FanDuelBet $5, Get $250 in Bet Reset Tokens over 5 Days
$250
DraftKings — Spend $5, Get $150 In Bonus Bets
DraftKings
DraftKingsSpend $5, Get $150 In Bonus Bets
$150
When you click our links to visit an operator and sign up, we may receive a commission at no extra cost to you. This financial relationship helps support our site.
Pickswise
Get exclusive 
free sports picks
to your email
subscriber 1
subscriber 2
subscriber 3
18K users have
already subscribed
Enter your email address
By signing up you agree to our terms and privacy