NYJ vs DET Prediction, Odds and NFL Picks for Sunday, 09/27/26

Both of these teams lost in Week 2 following opening-week victories. The Lions scored 31 points for the second straight game, but couldn’t slow down the Buffalo offense in a 41-31 road defeat. The Jets failed to hold onto a 17-7 fourth-quarter lead in a 20-17 overtime setback to the Packers, spoiling a potential 2-0 start for the first time since 2015.

Detroit allowed 446 yards to Buffalo and didn’t produce a single takeaway after causing three New Orleans turnovers in Week 1. The Jets yielded 17 points in the first seven quarters before Green Bay’s 10-spot in the fourth quarter to eventually force overtime.

The Lions head into Sunday’s matchup owning the 31st-ranked defensive EPA/Rush, but the Jets sit 29th offensively in EPA/Rush. Detroit started last season 3-0 against the spread at home, but the Lions are 1-5 ATS in the past six games at Ford Field. The Jets hit the road and concerningly went 1-7 in head coach Aaron Glenn’s initial campaign of 2025.

Lions QB Jared Goff averaged 279.4 passing yards at home last season, but was held to 206 yards in the season opener against New Orleans. The Jets have allowed the second-fewest passing yards per game (131.5), while the Lions rank seventh in average passing yards (246.5). Detroit owns a 12-3 ATS mark since the start of 2023 off a loss.

Jets vs Lions prediction: Lions -6.5 (-110) available at time of publishing. Playable at that number to -120.

Detroit has cashed the over in each of the first two games, finishing with combined totals of 61 and 72 points. The Lions topped the 30-point mark eight times last season and have already reached that number twice. The Jets have put up a total of 40 points through two games, including three points in the fourth quarter each time.

Detroit will look to run the ball against this New York rush defense, which sits third in EPA/Rush. Both the Lions and Jets rank in the top 10 in EPA/Pass (Detroit fifth, New York ninth), while Detroit’s defensive EPA/Pass is 23rd.

In his last 16 games against teams ranking in the top 15 in rushing yards allowed, Lions RB Jahmyr Gibbs is averaging 72.4 rushing yards per game. Gibbs was held to 52 yards on the ground against Buffalo after putting up 152 yards in the opener against the Saints.

The total in each of Detroit’s first two games closed at 49.5 and 55.5, but this is their lowest total of the season at 47.5. This marks only the third game with a total of 47.5 under Jets coach Aaron Glenn, which went 1-1 in 2025.

The Jets allowed 27 or more points in seven of eight road games last season, but gave up 10 points at Tennessee in the season opener. However, the Titans are second-to-last in yards per game through two weeks (243.0), compared to 362.0 yards per game by Detroit. Look for the points to be put up in this interconference matchup in the Motor City.

Jets vs Lions prediction: Over 47.5 (-110) available at time of publishing. Playable to 48.5 (-110).