Buffalo Sabres vs Pittsburgh Penguins Prediction, Odds and Picks for Wednesday, 11/26/25

The Buffalo Sabres hit the road for the Steel City looking to get a rare win on the road, as the Sabres are just 1-5-2 in the past 8 games away from home. Pittsburgh won the season series 2-1 in 2024-25, with Pittsburgh winning the only battle at PPG Paints Arena 6-5 in overtime on October 16, 2024. The Pens have won 3 of the past 4 meetings on home ice, too. In this series, the over cashed in all 3 meetings last season. Buffalo has cashed high in 6 of the past 8 games, too, lighting the lamp at a feverish pace since November 8, going for 33 goals in the 8-game span, or 4.1 GPG. They’ve also allowed 32 goals, or 4.0 GPG, which is a great recipe for the over.

The Penguins have cashed the under in 6 straight games, going 1-2-3 in the span, scoring a total of just 10 goals while allowing 15, or 2.5 GPG. However, facing the leaky defense and goaltending of the Sabres might jump-start Pittsburgh’s flagging offense. Last season, the over was a frequent occurrence when these teams got together, and we’ll go high on the total again, as Buffalo games continue to be high-scoring, and there is no sign of slowing down.

Sabres vs Penguins prediction: Over 6.5 (-105) at time of publishing. Playable to -110.

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