Buffalo Sabres vs Pittsburgh Penguins Prediction, Odds and Picks for Today, 03/05/26

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The Buffalo Sabres head down to PPG Paints Arena in Pittsburgh to battle the Penguins, and for the first time in many years, this could potentially be a playoff series preview. Both of these teams are playing well, and Buffalo is looking to make the postseason for the first time since 2011. The Sabres hit the Steel City on a roll, winning 4 in a row, while outscoring the competition 14-7. However, their last loss came on home ice against these Penguins on Feb. 5, and it was a bad 5-2 loss with Alex Lyon in between the pipes. Expect to see Ukko-Pekka Luukkonen in there.

For the Penguins, they were on the short end of a 2-1 loss in Boston last time out, and they’re in the midst of a hot streak, too, going 3-1-2 in the past six games, and 16-4-4 in the past 24 games, collecting 36 out of a possible 48 points to stay near the top of the Metropolitan Division. The Penguins have won four of the past five meetings, including four of the previous five meetings in the Steel City, too. Take Pittsburgh on home ice in this Eastern Conference showdown.

Sabres vs Penguins prediction: Pittsburgh Penguins ML (-115) at time of publishing. Playable to -120.

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