Colorado Avalanche vs New York Islanders Prediction, Odds and Picks for Today, 12/04/25

The Colorado Avalanche will kick off a 4-game road trip in Long Island as they visit the New York Islanders. The Avalanche have been off to a very impressive start, led by Hart Trophy candidate Nathan MacKinnon. Through his first 26 games, he has 46 points. He is supported by linemate Martin Necas — who has 33 on the season — and superstar defenseman Cale Makar with 32. As a team, they have only lost one game in regulation time, and they are 9-0-1 in their last 10 games. They are both the best offensive and defensive team in the league, averaging an insane 2.04 goals against per game — 0.48 less goals against per game than the next closest team. Colorado has been a powerhouse.

The Islanders took down a very good team in the Tampa Bay Lightning in their last game on home ice, but the Avalanche are on a different level. The 2.85 goals per game that the Islanders offense averages will not be enough to keep pace with the Avalanche, so I will take Colorado to win this one in regulation.

Avalanche vs Islanders prediction: Avs 3-way ML (-120) available at time of publishing. Playable at that number.

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