Ottawa Senators vs Vegas Golden Knights Prediction, Odds and Picks for Wednesday, 11/26/25

Closing out a massive Wednesday in the NHL is an intra-conference matchup between the Ottawa Senators and Vegas Golden Knights. It is the first of 2 matchups this season, and should be a dynamic matchup between 2 highly-skilled rosters. To get you set for all the action, we have provided our Senators vs. Golden Knights prediction.

Vegas is kicking off a 4-game home stand, and I see Golden Knights doing so with a win. After a run of 3-0-2, Vegas has dropped the last 2 games (0-1-1), and are losing ground in an extremely tight Pacific Division. The Knights have now returned home, and should be ready to start a strong stretch of hockey. The team is relatively healthy, as opposed to Ottawa who is still missing its captain Brady Tkachuk, with Thomas Chabot and Ridly Greig listed as day-to-day. Vegas has scored more than Ottawa, have a better power play, and have performed far better in both goals against average and penalty kill. The stats don’t tell the whole story, but I also think Vegas’ star power is greater, meaning it can take over games more than Ottawa can. This will be a fun one, but for our Senators vs. Golden Knights prediction, take Vegas on the money line.

Senators vs. Golden Knights prediction: Vegas Golden Knights ML (-170) available at time of publishing. Playable to (-185).

If you’re looking for a new sportsbook, check out Bet365, the world’s #1 sportsbook. They have an amazing sign-up offer where you can INSTANTLY receive $150 in bonus bets from a $5 wager, regardless of whether that bet wins or loses! There’s no catch, it’s really that simple. Join Bet365 right now ⏰ in time to fade or follow our experts’ Senators vs. Golden Knights predictions.