St. Louis Blues vs Tampa Bay Lightning Prediction, Odds and Picks for Today, 12/22/25

The St. Louis Blues and Tampa Bay Lightning clash to help kick off a new week in the NHL. These teams have yet to meet this season, and with both playing well we should be in for a great matchup. To get you set, here is a Blues vs Lightning prediction.

St. Louis was successful against the other Florida team in a 6-2 win over the Panthers, but I don’t expect the same success in this one. Tampa Bay has been near or at the top of the Eastern Conference and Atlantic Division but has been losing ground of late. The Bolts are a decent 3-2-1 in their last 6 games but are just getting over a 3-game losing streak (0-2-1) that they will still be eagerly looking to recover from. While the Blues have been decent of late, I believe there are still many inconsistencies in their game — proven by 2 recent losses to a mediocre Nashville team that outscored them 12-4. I expect a strong effort from Tampa Bay on home ice, giving St. Louis a number of issues and exploiting those inconsistencies. For this Blues vs Lightning prediction, I’m taking Tampa Bay to win in regulation.

Blues vs Lightning prediction: Lightning 3-way ML (-160) available at time of publishing. Playable to -170.

If you’re looking for a new sportsbook, check out Bet365, the world’s #1 sportsbook. They have an amazing sign-up offer where you can INSTANTLY receive $150 in bonus bets from a $5 wager, regardless of whether that bet wins or loses! There’s no catch, it’s really that simple. Join Bet365 right now ⏰ in time to fade or follow our experts’ Blues vs Lightning predictions.