Arsenal vs Atletico Madrid Prediction, Odds and Picks for Today, 10/21/25

Saturday’s 1-0 win over Fulham made it 5 wins in a row for Arsenal and while that result may not seem spectacular on the surface, it was another impressive performance from the Premier League title favorites. The Gunners won the xG battle 1.8-0.4 at Craven Cottage and Mikel Arteta’s side look by far the best team in the EPL. The Premier League title is their goal but Arteta is ambitious and so are his players, so there is a good possibility they also like their chances in the Champions League, where they have also made a fast start. Professional performances have been the motive in Europe, where Arsenal have beaten both Athletic Bilbao and Olympiakos 2-0, and that is sure to be what they put in against Atletico Madrid on Tuesday.

Atleti have picked up form of late, winning 4 times during a 5-match unbeaten run, but their road form leaves them looking vulnerable for a trip to the Emirates, where the Gunners are unbeaten in 6. Diego Simeone’s side are still searching for a first away win of the season and that is unlikely to arrive in north London.

Bet like a Caesar with this AMAZING new customer offer from Caesars Sportsbook. If you bet just $1, you’ll receive DOUBLE YOUR WINNINGS on your next 20 bets! Become a Caesars member 👥 using the Caesars promo code PWCONTENT20X, where you can bet on our Arsenal vs Atletico Madrid picks.