Liverpool vs Atletico Madrid Prediction, Odds and Picks for Wednesday, 09/17/25

Liverpool were held at bay for 95 minutes at Turf Moor, requiring a last-gasp winner from the penalty spot from talisman Mohamed Salah to beat Burnley, but neutrals could be in for a more entertaining matchup when the Reds begin their Champions League campaign on Wednesday. Visitors Atletico Madrid, unlike the defensively minded Clarets, have scored in all 4 competitive games this season and clinched their first victory of the campaign at home to Villarreal on Saturday, but a trip to Anfield is a more difficult prospect.

Arne Slot’s men have won 4 of their 5 competitive games this season and scored 9 goals, including a massive result against Arsenal before the international break. They have recorded shutouts in their last 2 matches, but before that, they had shipped 6 goals in 3 games, and they may be vulnerable at the back again on Wednesday. The Reds have won their last 3 meetings with Atletico Madrid, and Los Colchoneros have had a difficult start to the campaign, so backing Liverpool to win and both teams to score looks solid value.

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