PSV vs Atletico Madrid Prediction, Odds and Picks for Tomorrow, 12/09/25

PSV thrashed Napoli 6-2 in their last European encounter at the Philips Stadion and that victory forms part of a 4-match winning streak at home for Peter Bosz’s side, who will like their chances of overcoming La Liga giants Atletico Madrid. Diego Simeone’s visitors have stumbled in their last 2 outings, going down at Barcelona and Athletic Bilbao, while their 2 road fixtures in the league phase of the Champions League have ended in defeats to Liverpool (3-2) and Arsenal (4-0).

It is 14 matches in all competitions without defeat for PSV, who put in a fantastic display in matchday 5 to beat Premier League champions Liverpool 4-1 at Anfield to boost their hopes of an automatic last-16 spot. USA international Ricardo Pepi netted for the 2nd match in a row in Saturday’s 2-0 win at Heerenveen, taking his tally for the season to 7 in all competitions and leaving him joint-3rd in the club’s scoring charts. He could make an impact and help propel PSV to victory over Atletico.

PSV vs Atletico Madrid prediction: PSV ML (+210) available at time of publishing. Playable to +180.

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