Manchester United vs Chelsea Prediction, Odds and Picks for Saturday, 09/20/25

Ruben Amorim’s dismal win ratio at Manchester United looks unlikely to receive a boost on Saturday when the Red Devils entertain Chelsea in a crucial Premier League clash. It is a great opportunity for Chelsea to get back on track after last week’s tie with Brentford, because any more dropped points would leave them trailing in the wake of Liverpool. United’s defeat in last weekend’s Manchester derby was not unexpected, but the manner in which they caved in was unacceptable in the eyes of their fans. The board are sticking by Amorim for now, but another performance like that could be the final straw.

The stats from United’s 3-0 loss to Manchester City, which suggest it should have been a much closer result, paint a false picture because City were always comfortable. Pep Guardiola had been outmaneuvered by Thomas Frank and Fabian Hurzeler in City’s 2 previous league games, but Amorim was unable to find any answers. United’s players look shackled by his system and prone to the sort of mistakes that are borne out of not being certain of their responsibilities. If the Portuguese coach has not been able to drum it into them in his first 10 months in charge, then the week he has had following Sunday’s defeat is unlikely to make a difference.

Chelsea remain a work in progress too, but they look happy in Enzo Maresca’s structure and capable of flexibility when the coach wants it. The Blues matched Bayern Munich for most of Wednesday’s 3-1 defeat at Allianz Arena, only to be undone by a couple of individual mistakes at the back. All things considered, Chelsea should be the better team and can pick up the victory at Old Trafford.

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