Arsenal vs Manchester City Prediction, Odds and Picks for Sunday, 09/21/25

Arsenal and Manchester City both opened their Champions League campaigns with a win in midweek, but the going may be tougher on Sunday when they meet in this huge EPL clash. The Citizens have already lost twice this season and could fall 9 points behind Liverpool if they lose at the Emirates, while the hosting Gunners will hope to keep pace with the defending champions by inflicting another defeat on Pep Guardiola’s side. However, goals may be difficult to come by after both teams recorded their 2nd successive shutout in midweek.

Mikel Arteta’s team has conceded just 1 goal in 5 competitive matches this season, with 3 of those outings featuring fewer than 3 goals, while Manchester City have kept 3 clean sheets in their 5 games. While last season’s meetings between this pair produced a massive 10 goals, the 3 encounters before that featured 3 goals in total, and another low-scoring matchup looks the best bet on Sunday.

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