Southampton vs Manchester City Prediction, Odds and Picks for Tomorrow, 05/10/25

Southampton’s disappointing Premier League campaign suffered yet another blow as they were beaten 2-0 by fellow strugglers Leicester last time out and the Saints are unlikely to pose any threat to Manchester City. The Citizens are unbeaten in their last 29 meetings against teams that started the day bottom of the table and they look unlikely to slip up in this one. They have won their last 12 games against the bottom team in the division by an aggregate score of 44-1.

Southampton are looking to avoid the infamy of finishing level on points with Derby’s record-low of just 11, but it hard to have much hope for Simon Rusk’s men in this clash given the fact that they have lost 28 of their 35 league games and have conceded 82 goals in that run. The hosts have only netted 28 times and as a result have both the worst attacking and defensive record in the division, with a goal difference of -57. They face a Manchester City team who are on the up after what has been a disappointing campaign and are now focused on securing a Champions League spot while also having their sights set on Arsenal in 2nd place, who are just 3 points ahead.

City have tightened things up at the back, recording shutouts in 5 of their last 7 games in all competitions, and they should be able to record another on this trip to the south coast. Take Guardiola’s team to move a step closer to securing Champions League football.

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