Manchester City vs Manchester United Prediction, Odds and Picks for Sunday, 09/14/25

Despite being only 3 games into the new Premier League season, Manchester City already find themselves 6 points off the title pace being set by champions Liverpool and their desperation for victory adds an extra element of spice to this derby duel with Manchester United. Hopes were high after City produced a flawless performance to dismiss the challenge of Wolves 4-0 in their Premier League opener, but defeats against Tottenham and Brighton have followed, which emulate last season’s inconsistencies. Spurs were able to utilize the counter-attack to great effect in a 2-0 win at the Etihad, with City’s out-of-possession work the source of their struggles, while a quadruple substitution from Brighton provided them with the energy needed to come from behind in a 2-1 victory. It is back to the drawing board for City and, while Rodri has returned and able to start, it would be unjust to expect him to resume at the levels he had shown previously after 8 months out.

Fierce rivals Manchester United also arrive with plenty to prove, having scrambled to a 3-2 win at home to Burnley prior to the international break to make it 4 points from 3 games. Having also exited the EFL Cup at the hands of League Two club Grimsby, pressure is already mounting on Red Devils boss Ruben Amorim as he bids to get his side back into Europe and make some long-awaited progress. Given the Citizens’ summer revamp, there is a sense that Guardiola is still unsure on his best starting line-up but, with Erling Haaland on the scoring trail and renowned for starting a season strongly, they should find a way past this error-prone United defense.

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