Manchester City vs Napoli Prediction, Odds and Picks for Today, 09/18/25

Kevin De Bruyne makes a quick return to the Etihad Stadium on Thursday when his former club Manchester City host his new employers Napoli in the league phase of the Champions League. The Belgian has made a bright start to life in Serie A, although it is clear that he was unhappy about how his glittering 10-year stint at City came to an end. He will want to remind his old boss Pep Guardiola of his qualities in this clash.

Napoli have made a great start to the defense of their Serie A crown with 3 wins out of 3, including a 3-1 victory over Fiorentina on Saturday night that featured goals for De Bruyne and ex-Manchester United striker Rasmus Hojlund. His record of five goals in six previous Champions League games is outstanding too and it would be no surprise to see him flourish away from Old Trafford.

However, Hojlund’s record and finishing prowess pales in comparison to Erling Haaland’s. The City hitman has bagged 49 goals in 48 Champions League games and, with 3 strikes in 2 previous games against Napoli, should be able to lead City to victory here. Haaland has scored 8 goals in his last 3 matches for club and country and, after destroying United in the Manchester derby on Sunday, will likely give the Citizens the quality edge to beat their Italian opponents.

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