Bayer Leverkusen vs Newcastle United Prediction, Odds and Picks for Today, 12/10/25

Having stunned Manchester City in a 2-0 victory at the Etihad a fortnight ago, Bayer Leverkusen get set for another showdown with Premier League opposition and the Bundesliga club may also have the measure of Newcastle. Bayer Leverkusen have fallen 14 points behind leaders Bayern Munich in the German league following 3 defeats in 5 matches but they have suffered only 1 defeat in 5 Champions League outings, recording successive victories over the Citizens and Benfica.

Newcastle have made a better start to their European campaign, winning 3 of their 5 matches, but they would have been expected to record home victories against Athletic Bilbao and Benfica while Union Saint-Gilloise provided a perfect opportunity on their travels. Eddie Howe’s team won 4-1 at Everton in their last road game but they have struggled away from St. James’ Park this season, having suffered 4 defeats in a row prior to that, which includes a 2-1 reverse at Marseille in the Champions League.

Leverkusen have taken a backwards step this season, with Kasper Hjulmand taking time to adjust after replacing Xabi Alonso as manager, but they are still a force to be reckoned with following 8 wins in their last 13 matches. The German club capitalized on a much-changed City on matchday 5, winning 2-0 at the Etihad thanks to goals from Alejandro Grimaldo and Patrik Schick, and just 2 wins in 9 away games show that Newcastle could be vulnerable on their trip to the BayArena. Both teams have scored in 6 of Leverkusen’s 9 matches on home turf and that includes each of this season’s Champions League home games with PSV and PSG, so it’s worth backing that to happen again to really boost the odds.

Bayer Leverkusen vs Newcastle prediction: Bayer ML & BTTS (+355) available at time of publishing. Playable to +320.

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