Auburn Tigers vs Purdue Boilermakers Prediction, Odds and Picks for Today, 12/20/25

It’s a big-time matchup as No. 21 Auburn gets ready to take on No. 6 Purdue at a neutral-site Indy Classic game. Both teams have a deep roster that’s loaded with talent, capable of putting up points, but this matchup will ultimately come down to defense. Auburn’s senior Keyshawn Hall, a transfer from UCF, is having himself a big year, averaging 20.9 points, and 8.8 rebounds per game and will keep this Boilermakers defense busy. The Tigers are averaging 86.5 points per game, slightly above Purdue who is averaging 84.6 points, but the defensive gap between these two teams is noticeable.

Auburn is just 1-3 against ranked opponents this season, and two of those losses came against then-No. 7 Michigan (30-point loss) and then-No. 2 Arizona (29-point loss). Purdue, on the other hand, is 2-1 against ranked opponents with their only loss coming against then-No. 10 Iowa State (23-point loss). Leading this Boilermakers team is Fletcher Loyer who is averaging 14.1 points and 2 rebounds per game. The big difference in this matchup is Purdue’s ability to constantly pressure their opponents in man-to-man coverage. We’ve seen Auburn struggle against top-tier teams this season, and they’re allowing 76.8 points per game compared to Purdue’s 67.1. The Tigers will look to get the Boilermakers into foul trouble, but they’re disciplined enough and are holding opponents to 40.4% shooting from the floor this season. Look for Purdue to shoot the ball at a high clip as they’re making 50.5% of their shots this season, and take care of business against Auburn on Saturday afternoon. 

Auburn vs Purdue prediction: Purdue -8.5 (-110) available at time of publishing. Playable at that number.