Clemson Tigers vs Syracuse Orange Prediction, Odds and Picks for Today, 12/31/25

It’s an ACC battle as Clemson gets ready to take on Syracuse on Wednesday night. The Tigers are coming off a few close calls over the last few games, beating Cincinnati by just three points and South Carolina by seven. Clemson isn’t known for an explosive offense, averaging just 79.7 points per game, but they’ve held their own this season with strong defensive play. The Tigers play tough man-to-man defense, holding opponents to a 39.7% shooting percentage and just 65.8 points per game. 

Syracuse isn’t exactly lighting up the scoreboard either, averaging 74.6 points per game. However, they did beat then-No.13 Tennessee earlier in the year by two points and lost to then-No. 3 Houston by just four in overtime. This is an evenly matched battle between both clubs, and Syracuse is a slight underdog at home, which is surprising to me. The Orange have the depth to give Clemson a tough time in this matchup, and this will likely be a low-scoring game, seeing how both teams’ defenses have played this season. William Kyle should be able to clean up the glass and generate a few extra second-chance opportunities, which will be the difference maker here. For that reason, I’ll be backing Syracuse to keep this game close in front of their home crowd.

Clemson vs Syracuse prediction: Syracuse +1.5 (-105) available at time of publishing. Playable at that number.