Clemson Tigers vs Syracuse Orange Prediction, Odds and Picks for Today, 12/31/25

It’s an ACC battle as Clemson gets ready to take on Syracuse on Wednesday night. The Tigers are coming off a few close calls over the last few games, beating Cincinnati by just 3 points and South Carolina by 7. Clemson isn’t known for an explosive offense, averaging just 79.7 points per game. However, the Tigers have held their own this season with strong defensive play. They play tough man-to-man defense, holding opponents to a 39.7% shooting percentage and just 65.8 points per game. 

Syracuse isn’t exactly lighting up the scoreboard, either, averaging 74.6 points per game. However, the Orange did beat then-#13 Tennessee earlier in the year by 2 points and lost to then-#3 Houston by just 4 in overtime. This is an evenly matched battle between both clubs, and Syracuse is a slight underdog at home, which is surprising to me. The Orange have the depth to give Clemson a tough time in this matchup, and this will likely be a low-scoring game seeing how both teams’ defenses have played this season. William Kyle should be able to clean up the glass and generate a few extra second-chance opportunities, which could be the difference maker. For that reason, I’m backing Syracuse to keep this game close in front of its home crowd.

Clemson vs Syracuse prediction: Syracuse +1.5 (-105) available at time of publishing. Playable at that number.

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