Connecticut Huskies vs DePaul Blue Demons Prediction, Odds and Picks for Today, 12/21/25

No. 5 UConn looks to continue its dominance over DePaul as the Huskies go for their 21st victory against the Blue Demons. UConn enters this matchup 11-1, averaging 79 points per game while shooting 49.7% from the field. As for DePaul, they’re 8-4 and are averaging 76.4 points per game while shooting 45.4% from the field.

Solo Ball leads the Huskies with 15.4 points and 3.5 rebounds per game, and UConn has three players averaging double figures. While the Huskies can score, they rely on their aggressive and adaptive defense to shut down their opponents. According to KenPom, UConn is ranked 6th in adjusted defensive efficiency, and they’ll create a lot of frustration for the Blue Demons in this matchup. DePaul has three players averaging double digits, and leading their team is CJ Gunn, who is averaging 14.3 points and 3.4 rebounds per game. UConn has had a significantly harder schedule than DePaul, facing five top-25 teams compared to DePaul’s one. DePaul is coming off a 13-point loss to then No.22 St. John’s, and this should be a similar outcome for them this afternoon. Look for UConn to control the pace in this game and be too much for the Blue Demons to handle, making the Huskies my best bet of the day. 

UConn vs DePaul prediction: UConn -14.5 (-110) available at time of publishing. Playable at that number.