Creighton Bluejays vs Xavier Musketeers Prediction, Odds and Picks for Today, 12/17/25

Xavier will look to keep things rolling as it welcomes Creighton to the Cintas Center on Wednesday night in the Big East opener for both teams. The Musketeers appear to have found their rhythm, winning 5 straight games while averaging 83.2 points per cotest in that span. As for Creighton, it is coming off a tough shooting performance against Nebraska — making just 30.8% from the floor after shooting 39.7% against Kansas State this past Saturday. Tre Carroll has been a key piece in Xavier’s offense this season, averaging 16.9 points and 5.7 rebounds per game. Josh Dix is leading the Bluejays with 12.3 points and 3.0 rebounds per game and is the only player averaging double-digit points per game for his team. 

Creighton has faced a much more challenging non-conference schedule, taking on teams like Gonzaga, Iowa State and Nebraska. Xaver did beat solid West Virginia and Cincinnati teams, but those opponents don’t come close to the level of competition Creighton has already seen. Despite Xavier playing well of late, this Creighton team remains very talented. Austin Swartz is starting to heat up for the Bluejays, averaging 13 points in his last 3 games, and Isaac Traudt is coming off his best game of the season with 18 points. This should be a back-and-forth matchup. I see value with Creighton in this spot, which is why I’m taking the points on the road. 

Creighton vs Xavier prediction: Creighton +2.5 (-110) available at time of publishing. Playable at that number.

Now you can bet any of our Creighton vs Xavier predictions at FanDuel Sportsbook, which has a great new-customer offer to take advantage of. If you sign up for FanDuel right now, you earn a welcome bonus worth up to $300 if your first $5 bet wins! Use this link 🔗 to join FanDuel right now and learn more.