DePaul Blue Demons vs Georgetown Hoyas Prediction, Odds and Picks for Wednesday, 01/28/26

At first glance, DePaul checks every “public favorite” box. The Blue Demons have won 4 straight in the series, carry the better overall record and have been a far more reliable cover team at 13-7 ATS compared to Georgetown’s ugly 6-14 mark. Add in the fact that the Blue Demons are catching points and it feels like a simple click. That’s exactly the kind of setup that deserves a second look, because surface trends often mask context.

The biggest split in this matchup is venue. DePaul is just 1-4 straight up on the road, while Georgetown has been solid at home at 7-4 SU. That difference matters more than season ATS records because college teams tend to be highly environment-dependent. Travel, unfamiliar rims and hostile crowds hit teams that rely on rhythm and comfort — which fits DePaul’s profile. Schedule context also shifts perception. According to KenPom, DePaul’s non-conference strength of schedule ranks 362nd — meaning many of its wins have come against soft opposition. Georgetown, despite inconsistency, has faced stronger competition and is battle-tested in tougher spots. Put it together and the line actually makes sense even if it appears otherwise. DePaul’s numbers are inflated by favorable conditions, while Georgetown’s struggles are already priced in. In a home setting against a road-vulnerable opponent, the Hoyas are the side with the more trustworthy foundation.

DePaul vs Georgetown prediction: Georgetown -3.5 (-110) available at time of publishing. Playable to -4.

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