DePaul Blue Demons vs St. John's Red Storm Prediction, Odds and Picks for Today, 12/16/25

As we head toward conference play, the DePaul Blue Demons face the St. John’s Red Storm in a Big East matchup. St. John’s is off to a slower start than they had hoped, logging a 6-3 record thus far. Their losses have come to Iowa State, Alabama, and Auburn, so no hard there, but this team certainly has higher expectations. DePaul, on the other hand, has to be pleased with where they are at 8-3. They haven’t yet seen anyone on the level of the Johnnies, but this Blue Demons team is much improved over recent years. I don’t know if they can keep pace on the road though, and this spread number has me concerned because I could see it going either way. But I do like this game to be high scoring, so let’s take the game total over 153 points.

DePaul, for as bad as they were last season, has some program continuity working in its favor. They retained their leading scorer, and 3 of their top 4 scorers in fact, and they should at least be competent offensively. They shoot a ton of 3s, and they rebound well on the defensive end, so they will be surprisingly competitive in conference play. St. John’s, of course, is known for two things: superior defense, and a go-fast offense that attacks the rim. They have been over 90 points in 6 of their 9 games, and this is the kind of matchup that could easily be played at that kind of pace. We will need DePaul to pull its weight, but I think this is a team that can score this season, and they might surprise us. Let’s take the over.

DePaul vs St. John’s Prediction: Over 153 (-110) available at the time of publishing. Playable to 154.5.