DePaul Blue Demons vs Villanova Wildcats Prediction, Odds and Picks for Today, 12/31/25

DePaul enters this Big East matchup looking to prove it can stay competitive against the league’s upper tier despite recent results. The Blue Demons sit at 8-5 overall and have opened conference play 0-2, but those losses came against elite competition and were more competitive than final scores suggest. DePaul has shown defensive improvement, allowing around 69 points per game, and has relied on guard play to steady its offense. Layden Blocker leads the team in scoring and playmaking, while veterans like Kruz McClure provide perimeter defense and experience. DePaul’s ability to extend possessions through offensive rebounding and limit turnovers has been a key factor in keeping games within reach, especially when they can slow tempo and avoid extended scoring droughts.

Villanova comes in with a strong 10-2 record and has again established itself as one of the Big East’s most efficient teams on both ends of the floor. The Wildcats average mid-70s scoring while shooting well from three and defending the perimeter at a high level, regularly forcing opponents into tough half court possessions. Villanova has dominated this series historically and owns several recent lopsided wins over DePaul, but this year’s Blue Demons are more disciplined defensively and better equipped to withstand pressure. With Villanova often comfortable grinding games late once a lead is established, there is potential for a slower second half that favors the underdog. If DePaul can control pace, compete on the glass, and avoid early foul trouble, this matchup sets up for a more competitive result than the spread implies.

DePaul vs Villanova Prediction: DePaul +12.5 (-110) available at time of publishing. Playable to that number