Detroit Mercy Titans vs Michigan State Spartans Prediction, Odds and Picks for Today, 11/21/25

The Titans are a team with very little appeal as a Horizon League constituent that’s 1-4 on the season, every bit the kind of team that the Spartans should run over. This makes Detroit Mercy a side that will be taking back a bigger number by default in a spot not conducive for the Spartans to cover.

Michigan State? Well, the world bore witness to their dismantling of Kentucky in Madison Square Garden earlier this week. The Spartans led by 17 at half-time and closed a 4.5-point underdog. Going into the game, Big Blue was ranked inside the Top 10 despite the writing being on the wall that the Wildcats weren’t deserving of the number next to their name. Take away their namesake, who did they beat of consquence? No one. When they encountered reputable opposition in Louisville, the Cats were handled. What may seem like a shocker to some was, in reality, a confirmation of what was unspoken. Nevertheless, this is an overreaction spot with a 35-point swing to all but affirm it, in a let-down position for Michigan State. The Spartans can cruise through this game, win by 25, and no one would even bat an eye, but meanwhile if one was laying this amount of points, the ticket gets ripped. This is a Detroit Mercy or nothing kind of play and we’re taking the points with the Titans.

Detroit Mercy vs Michigan State prediction: Detroit Mercy Titans +30.5 (-110) available at time of writing. Playable to +30.

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