Duke Blue Devils vs Notre Dame Fighting Irish Prediction, Odds and Picks for Today, 02/24/26

Coming off its most impressive win of the season, No. 1 Duke shifts its focus to Notre Dame on Tuesday night. The Blue Devils took down then-No. 1 Michigan on Saturday by dominating inside, outscoring the Wolverines 34-24 in the paint and holding a 41-28 edge on the glass. Duke also grabbed 13 offensive rebounds, giving the Blue Devils a major edge in second-chance opportunities, and they’ll look to control the glass once again against a Fighting Irish team that allows opponents to shoot 43.5% from the floor this season.  

Notre Dame is coming off a 73-68 loss to Pittsburgh on Saturday, where they struggled from beyond the arc, knocking down just 9 of their 38 three-point attempts. The Fighting Irish will also be without two of their top scorers, Jalen Haralson and Markus Burton. Cole Certa has stepped up in their absence, but Notre Dame won’t have the depth or talent to keep pace with Cameron Boozer, Isaiah Evans, and Patrick Ngongba II. The Blue Devils have just proven they deserve to be the No.1 team in the nation, and this matchup sets up perfectly for them to assert their dominance once again. Duke should control the boards, limit Notre Dame’s perimeter shooting, and apply constant defensive pressure. With the Fighting Irish shorthanded and struggling offensively, I expect the Blue Devils to roll on the road. 

Duke vs Notre Dame prediction: Duke -17.5 (-115) available at time of publishing. Playable at that number.

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