Duke Blue Devils vs Pittsburgh Panthers Prediction, Odds and Picks for Today, 02/10/26

Where is Duke’s head right now? That’s the central question in this matchup, and the recent emotional swing matters. Just days ago, the Blue Devils suffered a crushing loss at North Carolina, where the Tar Heels rallied from a double-digit deficit and won on a near buzzer-beater after never leading until the final moment. The aftermath carried enormous major emotional weight. That kind of finish doesn’t just show up in the box score; it lingers. Now Duke has to quickly reset and hit the road for a game that profiles as a classic sandwich spot. On deck is a high-profile matchup Saturday in Durham against a ranked Clemson team, a game that will command far more internal focus. It’s human nature for attention to drift toward what’s next while dwelling on what has already been.

That’s where Pittsburgh becomes dangerous. Philosophical positions aside, the Panthers’ 9-15 record won’t intimidate anyone, but at home they have shown the ability to be physical, scrappy and energized — especially when a blue blood comes to town. Underdogs in this role often treat the game like a measuring stick. Add in a potentially flat favorite spotting what is assuredly an inflated number, and the value is clear with the Panthers. Duke should win, but doing so at this margin is the concern.

Duke vs Pittsburgh prediction: Pittsburgh +17 (-110) available at time of publishing. Playable at that number.

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