Gonzaga Bulldogs vs Kentucky Wildcats Prediction, Odds and Picks for Today, 12/05/25

The Friday headliner features the Gonzaga Bulldogs and the Kentucky Wildcats. Kentucky just suffered a home loss to North Carolina earlier in the week, and now it gets the Zags coming to town. For the Wildcats, that is 3 games against ranked opponents…and 3 losses. For the Zags, they have not played since the Players Era festival in Vegas before Thanksgiving. They got dragged by Michigan in the first-place game of that one, losing by 40. Otherwise, though, Gonzaga has dominated everyone it has faced. I look for the Bulldogs to get back on track on Friday, even in a tough road matchup. This line opened at -3.5 and it has shot up, but I will still take Gonzaga -5.5.

For the Wildcats, there have been a lot of early injury struggles. They will be down a couple players again on Friday — and although this team is deep at every position, the injuries catch up against a veteran team like Gonzaga. The Zags play fast and we know they can score, but they are also a top-10 defense through the first month of the season. That could be a problem for a Kentucky team that went nearly 10 minutes without a made basket in the second half against Carolina. UK is going to get things together as conference play approaches, but Friday should belong to the Zags.

Gonzaga vs Kentucky prediction: Gonzaga -5.5 (-110) available at time of publishing. Playable at that number.

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