Harvard Crimson vs St. John's Red Storm Prediction, Odds and Picks for Today, 12/23/25

This is less about falling in love with the underdog and more about recognizing a classic scheduling trap. The St. John’s Red Storm are coming off an emotionally charged loss to Kentucky — a game that carried real program-defining weight. They led at halftime, had a chance to secure a landmark win, and instead walked away deflated with a 12-point loss. That type of letdown often produces flat follow-up performances, especially when the next opponent doesn’t demand maximum focus.

That’s exactly the case here against the Harvard Crimson. With Georgetown looming next — a rival enjoying a resurgence and carrying both ranking and bragging-rights implications — this is a textbook sandwich spot. The assignment for St. John’s is simple: reset, survive and move on. Laying 25 points in that context is dangerous, particularly against a Harvard team that defends at an elite level. The Crimson rank among the nation’s top 40 in scoring defense, they rebound well, and have already shown they can compete physically with Power Conference programs, nearly stealing a win at Penn State. Harvard doesn’t need to threaten an outright upset; they just need to avoid being overwhelmed. Given the spot, the number, and the matchup profile, the value clearly sits with the points.

Harvard vs St. John’s prediction: Harvard +25 (-110) available at time of publishing. Playable at that number.

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