Houston Cougars vs Oklahoma State Cowboys Prediction, Odds and Picks for Today, 03/07/26

No. 7 Houston will close out the regular season against Oklahoma State as it looks to avoid an upset before heading into the Big 12 tournament. The Cougars were slow out of the gate against Baylor on Senior Night but dominated in the second half, outscoring the Bears 42-29. Houston hasn’t been particularly explosive offensively this season, averaging 77.5 points per game compared to Oklahoma State’s 84.2. However, defense is where the Cougars separate themselves from the rest of the Big 12. Houston is one of the defensive teams in the nation, allowing just 62.3 points per game, while the Cowboys are giving up 82.5.  

Oklahoma State will need to find a way to penetrate Houston’s defense, and that won’t be easy. The Cowboys struggled offensively against strong defensive teams like Cincinnati, Arizona, and Kansas in recent games. However, they did shoot 49.2% against West Virginia, a team that ranks second in the Big 12 in defense. Parsa Fallah has been playing well for the Cowboys, averaging 20 points per game in his last four, someone the Cougars will need to keep a close eye on. Houston may not have a great offense, and they struggled to contain Baylor’s offense early on in their last game, but this Cougars team won’t let that happen again. Look for them to slow down the pace and wrap up the regular season game with a big road win and secure a second-place finish in the Big 12. 

Houston vs Oklahoma State prediction: Houston -12.5 (-115) available at time of publishing. Playable at that number.