Howard Bison vs Duke Blue Devils Prediction, Odds and Picks for Today, 11/23/25

Duke is coming off a dominating performance against Niagara, where they won 100-42. The Blue Devils have been one of the best shooting teams this season, averaging 93.7 points per game and shooting 51% from the field. On Sunday, they’ll get ready to face Howard out of the MEAC conference, a game they shouldn’t have too much trouble with. The Bison are averaging 74.4 points per game while giving up 72, and this will be their toughest matchup on the season. 

The Bison opened their season with a 21-point loss to Missouri, and Duke is a much stronger and deeper team than the Tigers. The Blue Devils have three players averaging double digits, and leading this offense is the freshman Cameron Boozer, who has been doing a little bit of everything. Boozer is averaging 20.3 points, 9.5 rebounds, and 4.0 assists per game. Even if Boozer isn’t efficient in this matchup, Duke’s depth will be difficult for Howard to keep up with. Bryce Harris leads this Howard team with 22.4 points and 7.8 rebounds per game, and he’ll be able to score some points for the Bison, but he can’t do it all himself. The Bison don’t have the depth or talent to keep things close with Duke, and even though it’s a massive spread, we just saw what Duke did against Niagara, and they should be able to do the same thing against Howard. 

Howard vs Duke prediction: Duke -42.5 (-110) available at time of publishing. Playable at that number.

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